Please refer to the printed manual for detailed information.
Background
GPNMB belongs to the PMEL / NMB family; also known as Osteoactivin and Hematopoietic growth factor-inducible neurokinin 1 ( HGFIN ); is a transmembrane glycoprotein that is expressed in numerous cells; including osteoclasts; macrophages; dendritic cells; and tumor cells. It is suggested to influence osteoblast maturation; cell adhesion and migration. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization; and functions as a negative regulator of inflammation in macrophages. Osteoactivin is expressed at high levels in normal and inflammatory liver macrophages suggesting a significant role in acute liver injury. The early-phase upregulation of Osteoactivin expression in the tubular epithelium in response to renal injury might play a role in triggering renal interstitial fibrosis via activation of matrix metalloproteinase expression and collagen remodeling in rats. Osteoactivin as a protein that is expressed in aggressive human breast cancers and is capable of promoting breast cancer metastasis to bone.
Reactivity
Human
Tag
C-Fc
Description
A DNA sequence encoding the human GPNMB (Q14956-2) (Met1-Pro474) was expressed with the Fc region of human IgG1 at the C-terminus.
Formulation
Lyophilized from sterile PBS; pH 7.4
Host
HEK293 Cells
Accession Number
Q14956-2
Endotoxin Level
< 1.0 EU per ug as determined by the LAL method.
Mol Weight
77.8 kDa
Mw(kda)
77.8 kDa
Sequence Info
Met 1-Pro474
Shipping
This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.