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Home / Proteins & Peptide

Recombinant Human GLA (C-6His)

SKU : BHP15200291

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ELK Biotechnology

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Mfr.No.	EPT291
Description	Recombinant Human Alpha-Galactosidase is produced by our Mammalian expression system and the target gene encoding Leu32-Leu429 is expressed with a 6His tag at the C-terminus.
Alternative Names	Alpha-Galactosidase A; Alpha-D-Galactosidase A; Alpha-D-Galactoside Galactohydrolase; Melibiase; Agalsidase; GLA
Background	alpha-Galactosidase A is a homodimeric glycoprotein that belongs to the glycosyl hydrolase 27 family. It is a lysosomal enzyme and used as a long-term enzyme replacement therapy in patients with a confirmed diagnosis of Fabry disease. alpha-Galactosidase A can hydrolyze terminal alpha-galactosyl moieties from glycolipids and glycoproteins and catalyze the hydrolysis of melibiose into galactose and glucose. Defects alpha-Galactosidase A are the cause of Fabry disease (FD) which is a rare X-linked sphingolipidosis disease with glycolipid accumulates in many tissues. The disease consists of an inborn error of glycosphingolipid catabolism. FD patients show systemic accumulation of globotriaoslyceramide (Gb3) and related glycosphingolipids in the plasma and cellular lysosomes throughout the body. Patients may show ocular deposits, febrile episodes, and burning pain in the extremities. Death results from renal failure, cardiac or cerebral complications of hypertension or other vascular disease.
Biological Activity	Measured by its ability to hydrolyze 4-Nitrophenyl -alpha -D-galactopyranoside. The specific activity is 2835 pmol/min/ug.
Molecular Weight	46.39 KDa
Accession Number	P06280
Endotoxin Level	Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.

Shipping	The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
Purity	Greater than 95%
Storage	Store at <=-70°C, stable for 6 months after receipt. Store at <=-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

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SKU	Supplier No.	Size	Your price	Quantity
BHP15200291	EPT291	1mg	$4069		Add to Cart

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