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Home / Proteins & Peptide

Recombinant Human FGFR3/CD333 Protein (Fc Tag)(Active)

SKU : BHP10304631

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH033678
Description	Recombinant Human FGFR3 is produced by our Mammalian expression system and the target gene encoding Glu23-Gly375 is expressed with a Fc tag at the C-terminus.
Alternative Names	Fibroblast growth factor receptor 3; FGFR-3;FGFR3; JTK4; IIIc;ACH;CD333;CEK2;HSFGFR3EX
Reconstitution	Please refer to the printed manual for detailed information.
Background	Fibroblast growth factors (FGFs) are involved in a multitude of physiological and pathological cellular processes. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. Multiple forms of FGF R1-3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGF R1 and 2 results in receptors containing all three Ig domains, referred to as the alpha isoform, or only IgII and IgIII, referred to as the beta isoform. Only the alpha isoform has been identified for FGF R3 and FGF R4. Additional splicing events for FGF R1-3, involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons, generate FGF receptors with alternative IgIII domains (IIIb and IIIc). The complex patterns of expression of these receptors as well as the specificity of their interactions with the various FGF ligand family members are under investigation.
Reactivity	Human
Tag	C-Fc
Formulation	Lyophilized from a 0.2 um filtered solution of PBS, pH7.4.
Host	Human Cells
Accession Number	P22607
Endotoxin Level	< 1.0 EU per ?g as determined by the LAL method.
Bioactivity	Measured by its ability to inhibit FGF acidic-dependent proliferation of BALB/c 3T3 cells. The ED50 for this effect is 18.2 ng/ml.
Mol Weight	64.8 kDa
Mw(kda)	64.8 kDa

Sequence Info	Glu23-Gly375

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95% as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10304631	PKSH033678	10ug	$92		Add to Cart
BHP10304631	PKSH033678	50ug	$6		Add to Cart

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