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Home / Proteins & Peptide

Recombinant Human FGFR3/CD333 Protein (alpha(IIIb), Fc Tag)

SKU : BHP10300154

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH030490
Alternative Names	FGFR3 ; CD333
Antigen	FGFR3 / CD333
Background	FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. FGFRs are transmembrane catalytic receptors that have intracellular tyrosine kinase activity. Mutations in FGFR genes are the cause of several human developmental disorders characterized by skeletal abnormalities such as achondroplasia, and upregulation of FGFR expression may lead to cell transformation and cancer. FGFR3, a full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR3 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR3 binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in FGFR3 gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. CD333 is the receptor for acidic and basic fibroblast growth factors.
Tag	alpha(IIIb) tag ; Fc Tag
Description	A DNA sequence encoding the human FGFR3(alpha(IIIb)) (NP_001156685.1) (Met1-Gly377) was expressed with the Fc region of human IgG1 at the C-terminus.
Regulatory	RUO
Host	Human Cells
Endotoxin Level	< 1.0 EU per μg protein as determined by the LAL method.
Nature	Recombinant

Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Buffer	Lyophilized from sterile PBS, pH 7.4
Description	Please refer to the printed manual for detailed information.
Purity	> 95 % as determined by SDS-PAGE.
Expiry Date	Samples are stable for up to twelve months from date of receipt at -70℃

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10300154	PKSH030490	200ug	$1210		Add to Cart

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