Recombinant Human Dentin matrix acidic phosphoprotein 1(DMP1)

Mfr.No.	CSB-YP006967HU
Tag	N-terminal 6xHis-tagged
Description	May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite.
Regulatory	RUO
Relevance	May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite.
Source	Yeast
Abbreviation	DMP1
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Dentin matrix acidic phosphoprotein 1; Short name= DMP-1; Short name= Dentin matrix protein 1
Expression Region	17-513aa
Mol Weight	56.0 kDa
Nature	Recombinant
Protein Description	Full Length of Mature Protein

Involvement In Disease	Hypophosphatemic rickets, autosomal recessive, 1 (ARHR1)
Subcellular Location	Nucleus, Cytoplasm, Secreted, extracellular space, extracellular matrix
Uniprot	Q13316, Q13316
Database Links	HGNC:2932 OMIM:241520 KEGG:hsa:1758 STRING:9606.ENSP00000340935 UniGene:Hs.652366
Function	May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite.
Research Area	Signal Transduction
Tissue Specificity	Expressed in tooth particularly in odontoblast, ameloblast and cementoblast.
Weight	56 kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 85% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol