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Home / Proteins & Peptide

Recombinant Human/Cynomolgus CD28/TP44 (N-His)

SKU : BHP10304778

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH033840
Alternative Names	CD28; CD28 antigen; CD28 molecule; T-cell-specific surface glycoprotein CD28; Tp44; TP44
Reconstitution	Please refer to the printed manual for detailed information.
Background	T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type (immunoglobulin-like) domain. It belongs to the immunoglobulin(Ig) superfamily. CD28 is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation.CD28 co-stimulation is necessary for CD4 positive T-cell proliferation and survival, interleukin-2 production, and T-helper type-2 development. Human post-thymic regulatory T cells require CD28 co-stimulation to expand and maintain potent suppressive function in vivo. Apoptosis plays a key role in the age-related decline of CD28 expression and in immunosenescence. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
Reactivity	Human/Cynomolgus
Tag	N-6His
Description	Recombinant Human T-cell-specific Surface Glycoprotein CD28 is produced by our Mammalian expression system and the target gene encoding Asn19-Pro152 is expressed with a 6His tag at the N-terminus.
Formulation	Lyophilized from a 0.2 um filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Host	Human Cells
Accession Number	P10747
Endotoxin Level	< 1 IEU/ug as determined by LAL test.
Bioactivity	Immobilized Human/Cynomolgus CD28-His(Cat#C406) at 2ug/ml (100 ul/well) can bind Anti-CD28 mAb(Cat#A063). The ED50 of Anti-CD28 mAb(Cat#A063) is 15.3 ng/ml.
Mol Weight	16.7 kDa
Mw(kda)	16.7 kDa

Sequence Info	Asn19-Pro152

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	>95% as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10304778	PKSH033840	10ug	$132		Add to Cart
BHP10304778	PKSH033840	50ug	$393		Add to Cart

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