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Home / Proteins & Peptide

Recombinant Human ANPEP/CD13 Protein (603 Met/Ile, His Tag)(Active)

SKU : BHP10303085

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH031912
Alternative Names	APN;CD13;GP150;LAP1;P150;PEPN
Reconstitution	Please refer to the printed manual for detailed information.
Background	Aminopeptidase N (ANPEP or APN), also known as CD13, is a cell-surface metalloprotease located in the small-intestinal and renal microvillar membrane, as well as other plasma membranes. It belongs to the peptidase M1 family. CD13 plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases and is involved in the metabolism of regulatory peptides by diverse cell types. CD13/APN is a potent regulator of angiogenesis which is essential for tumor invasion and metastasis, and its transcription in activated endothelial cells is induced by angiogenic growth factors via the RAS/MAPK pathway. In addition, this enzyme has been shown to participate in antigen processing and presentation, and accordingly, defects in this gene appear to be a cause of various types of leukemia or lymphoma and carcinomas.
Reactivity	Human
Tag	C-His
Description	A DNA sequence encoding the metalloprotease domain (Lys 69-Lys 967?603 Met/Ile) of the mature form of human ANPEP (NP_001141.2) was expressed with N-terminal signal peptide and C-terminal polyhistidine tag.
Formulation	Lyophilized from sterile PBS, pH 7.3
Host	HEK293 Cells
Accession Number	NP_001141.2
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Bioactivity	Measured by its ability to cleave the fluorogenic peptide substrate, Ala-7-amido-4-methylcoumarin (Ala-AMC). The specific activity is >2,500 pmoles/min/ug.
Mol Weight	104.2 kDa
Mw(kda)	104.2 kDa

Sequence Info	Lys 69-Lys 967?603 Met/Ile

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 97 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10303085	PKSH031912	50ug	$1105		Add to Cart

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