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Home / Proteins & Peptide

Recombinant Cynomolgus Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33L3 (C-Fc)

SKU : BHP10306227

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSQ050112
Alternative Names	Sialic acid-binding Ig-like lectin 15; Siglec-15; CD33 antigen-like 3; CD33L3
Reconstitution	Please refer to the printed manual for detailed information.
Background	Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO?-terminus is cytosolic. Each Siglec contains an N-terminal V-type immunoglobulin domain (Ig domain) which acts as the binding receptor for sialic acid. These lectins are placed into the group of I-type lectins because the lectin domain is an immunoglobulin fold. All Siglecs are extended from the cell surface by C2-type Ig domains which have no binding activity. Siglecs differ in the number of these C2-type domains. Siglec-15 function is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts.
Reactivity	Cynomolgus
Tag	C-Fc
Description	Recombinant Cynomolgus Sialic Acid-binding Ig-like lectin 15 is produced by our Mammalian expression system and the target gene encoding Phe20-Thr263 is expressed with a Fc tag at the C-terminus.
Formulation	Lyophilized from a 0.2 um filtered solution of 50mM Tris-HCl, 100mM Glycine, 150mM NaCl, pH 7.5.
Host	Human Cells
Accession Number	A0A2K5UY47
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Bioactivity	Immobilized Cynomolgus Siglec-15-Fc(Cat#PKSQ050112) at 2ug/ml (100 ul/well) can bind Anti-Human Siglec15 mAb. The ED50 of Anti-Human Siglec15 mAb is 20.9 ng/ml.
Mol Weight	53.1 kDa
Mw(kda)	53.1 kDa

Sequence Info	Phe20-Thr263

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	>95% as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10306227	PKSQ050112	10ug	$132		Add to Cart
BHP10306227	PKSQ050112	50ug	$393		Add to Cart

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