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Recombinant Cynomolgus Fc gamma RIIIA/FCGR3A/CD16a (C-6His)

SKU : BHP10306214

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSQ050099
Alternative Names	Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A; CD16a Antigen; Fc-Gamma RIII-Alpha; Fc-Gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc Receptor III-2; CD16a; FCGR3A; CD16A; FCG3; FCGR3; IGFR3
Reconstitution	Please refer to the printed manual for detailed information.
Background	Receptors for the Fc region of immunoglobin G (FcgammaR) are divided into three classes and FcgammaRIII is a multifunctional, low/intermediate affinity receptor. In humans, FcgammaRIII is expressed as two distinct forms (FcgammaRIIIA and FcgammaRIIIB) that are encoded by two different but highly homologous genes in a cell type-specific manner. FcgammaRIIIB is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas FcgammaRIIIA is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed by a subset of T lymphocytes, natural killer (NK) cells, monocytes, and macrophages. The FcgammaRIIIA receptor is involved in phagocytosis, secretion of enzymes, inflammatory mediators, antibody-dependent cellular cytotoxicity (ADCC), mast cell degranulation, and clearance of immune complexes. FcgammaRIIIA has an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and delivers an activation signal in the immune responses. Aberrant expression or mutations in this gene is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia. In humans, it is a 50 -70 kD type I transmembrane activating receptor. The FcgammaRIIIA cDNA encodes 254 amino acid including a 16aa signal sequence, 191 amino acid ECD with two C2-type Ig-like domains, five potential N-glycosylation sites, a 22 amino acid transmembrane sequence and a 25 amino acid cytoplasmic domain.
Reactivity	Cynomolgus
Tag	C-6His
Description	Recombinant Cynomolgus Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A is produced by our Mammalian expression system and the target gene encoding Glu21-Gly206 is expressed with a 6His tag at the C-terminus.
Formulation	Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
Host	Human Cells
Accession Number	A0A140HDP8
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Mol Weight	22 kDa
Mw(kda)	22 kDa

Sequence Info	Glu21-Gly206

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	>95% as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10306214	PKSQ050099	10ug	$208		Add to Cart
BHP10306214	PKSQ050099	50ug	$624		Add to Cart

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