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Home / Proteins & Peptide

Recombinant Cynomolgus B7-1/CD80 Protein (His Tag)

SKU : BHP10306145

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSQ050029
Description	Recombinant Cynomolgus CD80 is produced by our Mammalian expression system and the target gene encoding Val35-Asn242 is expressed with a 6His tag at the C-terminus.
Alternative Names	T-lymphocyte activation antigen CD80; Activation B7-1 antigen; B7; CD80
Reconstitution	Please refer to the printed manual for detailed information.
Background	Cynomologous Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily.It is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells.CD80 plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
Reactivity	Cynomolgus
Tag	C-His
Formulation	Lyophilized from a 0.2 um filtered solution of PBS, pH7.4.
Host	Human Cells
Accession Number	G7NXN7
Endotoxin Level	< 1.0 EU per ?g as determined by the LAL method.
Mol Weight	24.7 kDa
Mw(kda)	24.7 kDa

Sequence Info	Val35-Asn242

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95% as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10306145	PKSQ050029	10ug	$62		Add to Cart
BHP10306145	PKSQ050029	50ug	$13		Add to Cart

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