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Home / Proteins & Peptide

Recombinant Bordetella pertussis Pertussis toxin subunit 1(ptxA)

SKU : BHP10502611

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-YP356423BUA
Alternative Names	Islet-activating protein S1 ,IAP S1NAD-dependent ADP-ribosyltransferase (EC:2.4.2.-), Islet-activating protein S1 ; IAP S1NAD-dependent ADP-ribosyltransferase (EC:2.4.2.-)
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD+ into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP-binding proteins from their mbrane receptors.
Source	Yeast
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Pertussis toxin subunit 1; Short name= PTX S1; Alternative name(s): Islet-activating protein S1; Short name= IAP S1; NAD-dependent ADP-ribosyltransferase; EC= 2.4.2.-
Expression Region	35-269aa
Mol Weight	28.2kDa
Nature	recombinant
Protein Description	Full Length of Mature Protein

Subcellular Location	Secreted
Uniprot	P04977, P04977
Database Links	KEGG:bpe:BP3783 STRING:257313.BP3783
Function	S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD(+) into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP-binding proteins from their membrane receptors.
Protein Families	Bacterial exotoxin subunit A family
Research Area	Others
Weight	28.2kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

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SKU	Supplier No.	Size	Your price	Quantity
BHP10502611	CSB-YP356423BUA	500ug	$1916		Add to Cart
BHP10502611	CSB-YP356423BUA	100ug	$826		Add to Cart
BHP10502611	CSB-YP356423BUA	20ug	$436		Add to Cart

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