Recombinant 2019-nCoV S1 Protein (C-6His)

Mfr.No.	EPT049
Description	Recombinant SARS-CoV-2 S1 Protein is produced by our Mammalian expression system and the target gene encoding Val16-Arg685 is expressed with a 6His tag at the C-terminus.
Alternative Names	S1 protein; 2019-nCoV S1 protein; coronavirus S1 Protein; cov S1 Protein
Background	The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
Biological Activity	Immobilized 2019-nCoV S1-His (Cat#DRA47) at 5ug/ml (100 ul/well) can bind Human ACE-2-Fc(Cat#C05Y).The ED50 of Recombinant Human ACE-2-Fc(Cat#C05Y) is 58.3 ng/ml.
Molecular Weight	75.8kDa
Accession Number	QHD43416.1

Shipping	The product is shipped on dry ice pack.Upon receipt, store it immediately at the temperature listed below.
Purity	Greater than 90%
Storage	Reconstituted protein solution should be stored at <= -20°C.

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SKU	Supplier No.	Size	Your price	Quantity
BHP15200049	EPT049	50ug	$399		Add to Cart