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Home / Proteins & Peptide

Recombinant 2019-nCoV Helicase (N-6His-MBP)

SKU : BHP15200080

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ELK Biotechnology

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Mfr.No.	EPT080
Description	Recombinant 2019-nCoV Helicase is produced by our E.coli expression system and the target gene encoding Ala5325-Gln5925 is expressed with a 6His, MBP tag at the N-terminus.
Alternative Names	SARS-CoV 2 Helicase; SARS-CoV 2 nsp13
Background	The nonstructural protein 13 (nsp13) of SARSCoV 2 is a helicase that separates doublestranded RNA or DNA with a 5'3' polarity, using the energy of nucleotide hydrolysis. A basic biochemical characterization of nsp13 demonstrated that it can unwind both doublestranded DNA and RNA in a 5 -3 direction, and it can hydrolyze all deoxyribonucleotide and ribonucleotide triphosphates. Helicases are motor proteins that utilize the energy derived from nucleotide hydrolysisto unwind double-stranded nucleic acids into two single-stranded nucleic acids. Initially, helicases were only thought to be molecular engines that unwind nucleic acids during replication, recombination, and DNA repair. Recent studies have shown that they are also involved in other biological processes, including displacement of proteins from nucleic acid, movement of Holliday junctions, chromatin remodeling, catalysis of nucleic acid conformational changes, several aspects of RNA metabolism, including transcription, mRNA splicing, mRNA export, translation, RNA stability and mitochondrial gene expression. Some human diseases, including Bloom s syndrome, Werner s syndrome, and Xeroderma Pigmentosum have been associated with defects in helicase function.
Molecular Weight	112.8 KDa
Accession Number	P0DTD1

Shipping	The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
Purity	Greater than 80%
Storage	Store at <=-70°C, stable for 6 months after receipt. Store at <=-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

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SKU	Supplier No.	Size	Your price	Quantity
BHP15200080	EPT080	50ug	$699		Add to Cart

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