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Home / Proteins & Peptide

Rat TGF-beta1 protein

SKU : BHP13700100

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Abbkine Scientific Co., Ltd.

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Mfr.No.	PRP100618
Description	Rat TGF-beta1 protein, expressed in HEK293 Cells
Alternative Names	Transforming growth factor beta-1; TGFB1
Background	TGF-beta1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-gamma, tumor necrosis factor-alpha and various interleukins. It can also decrease the expression levels of cytokine receptors. Meanwhile, TGF-beta1 also increases the expression of certain cytokines in T cells and promotes their proliferation, particularly if the cells are immature. TGF-beta1 also inhibits proliferation and stimulates apoptosis of B cells, and plays a role in controlling the expression of antibody, transferrin and MHC class II proteins on immature and mature B cells. As for myeloid cells, TGF-beta1can inhibit their proliferation and prevent their production of reactive oxygen and nitrogen intermediates. However, as with other cell types, TGF-beta1 also has the opposite effect on cells of myeloid origin. TGF-beta1 is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Once cells lose their sensitivity to TGF-beta1-mediated growth inhibition, autocrine TGF-beta signaling can promote tumorigenesis. Elevated levels of TGF-beta1 are often observed in advanced carcinomas, and have been correlated with increased tumor invasiveness and disease progression.
Immunogen Region	PRP100618
Tag	TGF-beta1
Formulation	Lyophilized from sterile PBS, pH 7.4
Molecular Weight	12.8 kDa
Usage	Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Rat TGF-beta 1 protein in sterile ddH2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.
Accession Number	P17246
Precautions	The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Bioactivity	Measured by its ability to inhibit cell proliferation of Mv-1-lu mink lung epithelial cells. The ED50 for this effect is 0.2-0.8 ng/mL.
Protein Length	The recombinant rat TGF-beta1 comprises 112 amino acids and predicts a molecular mass of 12.8 kDa.
Others	The Endotoxin level is less than 1.0 EU per ug of the protein as determined by the LAL method Preparation Method: HEK293 Cells

Sequence	Amino acid sequence derived from rat TGF-beta1 (Ala279-Ser390) was expressed. Rat and Mouse mature TGFB1 sequences are identical.

Purity	> 90 % as determined by SDS-PAGE
Storage	Lyophilized Rat TGF-beta1 proteinshould be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.94% HSA or BSA). Please prevent freeze-thaw cycles.

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SKU	Supplier No.	Size	Your price	Quantity
BHP13700100	PRP100618	5 ug	$169		Add to Cart
BHP13700100	PRP100618	100 ug	$1179		Add to Cart
BHP13700100	PRP100618	1 mg	$6249		Add to Cart

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