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Home / Proteins & Peptide

PrCP, His-tag

SKU : BHP18200823

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Mfr.No.	80380
Description	Human recombinant Lysosomal Pro-X carboxypeptidase, also known as angiotensinase C (GenBank Accession #NM_005040), a.a. 31-496 with C-terminal His-tag, MW=53 kDa, expressed in HEK293 cells.
Background	PrCP is a lysosomal prolylcarboxypeptidase that cleaves C-terminal amino acids linked to proline. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. PrCPs role in angiotension II cleavage, which regulates blood pressure and electrolyte balance, suggests that PrCP may be involved in hypertension.
Immunogen Region	31-496
Tag	C-terminal His-tag
Formulation	40 mM Tris pH 8.0, 110 mM NaCl, 2.2 mM KCl, 20% glycerol, 3 mM DTT, 200 mM imidazole
Species	Human
Application	Useful for the cleavage of C-terminal amino acids linked to proline in peptides, for example, angiotension II, III and des-Arg9-bradykinin.
Notes	Avoid freeze/thaw cycles.
GenBank	NM_005040
Mw(kda)	53 kDa

Synonyms	Proline Carboxypeptidase, Angiotensinase C, PCP, Lysosomal Pro-X carboxypeptidase
Uniprot	P42785

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	Stable at least 6 months from date of receipt, when stored as directed

Reference	1. Tan, F., et al. 1993. J Biol Chem 268 (22): 16631-8. 2. Yang, H.Y., et al. 1968. Nature 218 (5148): 1224-6. 3. Wang, L., et al. 2006. Am. J. Obstet. Gynecol. 195 (1): 162-71.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200823	80380	10 ug	$495		Add to Cart

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