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Home / Proteins & Peptide

PDE11A4, GST-tag

SKU : BHP18200538

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BPS Bioscience

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Mfr.No.	60110
Description	Human PDE11A (GenBank Accession No.BC112393), full length with N-terminal GST-tag, MW= 131 kDa, expressed in a Baculovirus infected Sf9 cell expression system. Host cell line: Sf9 Specific activity: >= 1560 pmol/min/ug Unit definition: One unit is defined as the amount of enzymethat will convert 1 pmole of 3' , 5' -cAMP to5' -AMP per minute at 37°C.
Immunogen Region	full length
Tag	N-terminal GST-tag
Formulation	25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, 10 mM glutathione, and 3 mM DTT
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	10 mM Tris-HCl, pH 7.4, 10 mM MgCl₂ , 0.1 mg/ml BSA,200 uM cAMP, 2.5 kU 5'-nucleotidase, and PDE11A at 37°C for 20 min.Quantified by 5'-nucleotidase cleaving the 5'-AMP product and releasing the phosphate groupwhich is detected by Malachite Green Reagent. Avoid freeze/thaw cycles.
GenBank	BC112393
Mw(kda)	131 kDa

Synonyms	PDE11, phosphodiesterase 11A
Uniprot	Q9HCR9

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Loughney K, et al., Int. J. Impot. Res. 2005, 17(4):320-5. 2. Weeks JL, et al., Int. J. Impot. Res. 2005, 17(1):5-9.Application Reference(s): 1.Genetic deletion and pharmacological inhibition of phosphodiesterase 10A protects mice from diet-induced obesity and insulin resistance (2014) 2.A yeast-based chemical screen identifies a PDE inhibitor that elevates steroidogenesis in mouse Leydig cells via PDE8 and PDE4 inhibition (2013) 3.The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey (2013)

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200538	60110	10 ug	$500.50		Add to Cart

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