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Home / Proteins & Peptide

PARP1, GST-tag

SKU : BHP18200842

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BPS Bioscience

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Mfr.No.	80501
Description	Human PARP1 (GenBank Accession No. NM_001618), full length with N-terminal GST-tag, MW = 140 kDa, expressed in a Baculovirus infected Sf9 cell expression system. Unit definition: One unit of PARP incorporates 100 pmoles of poly(ADP) in 1 minute from NAD into the acid-insoluble form.
Immunogen Region	full length
Tag	N-terminal GST-tag
Formulation	40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 4 mM glutathione, 20% glycerol, and 3 mM DTT.
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	Enzyme reaction is conducted usingBPS's PARP1 Assay Kit (Catalog #80551) at room temperature for 1 hour. Avoid freeze/thaw cycles.
GenBank	NM_001618
Mw(kda)	140 kDa

Synonyms	poly (ADP-ribose) polymerase 1, poly(ADP-ribosyl)transferase, ADPRT, PARP1
Uniprot	P09874

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Purity	>=80%
Storage	At least 6 months at -80°C.

Reference	1. Aguilar-Quesada R, et al., 2007. Curr Med Chem. 14(11):1179-87. 2. Pacher P. and Szabó C. 2007. Cardiovasc Drug Rev. 25(3):235-60.Application Reference(s):De Vos, M., et al. J Biol Chem. 2014 Jun 6;289(23):16223-38. doi: 10.1074/jbc.M113.527424. Poly(ADP-ribose) polymerase 1 (PARP1) associates with E3 ubiquitin-protein ligase UHRF1 and modulates UHRF1 biological functions (2014)Larsson, E.A., et al. J Med Chem. 2013 Jun 13;56(11):4497-508. doi: 10.1021/jm400211f. Fragment-based ligand design of novel potent inhibitors of tankyrases (2013)

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200842	80501	20 ug	$511.50		Add to Cart

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