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Home / Proteins & Peptide

OTOR, Human

SKU : BHP18500371

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iXCells Biotechnologies

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Mfr.No.	IX03222, IX03222-1
Description	Otoraplin (OTOR) is a cytokine first identified in 2000 and encodes a small protein of 128 amino acids with an SH3 domain. OTOR is a homologue to CD-RAP/MIA and contains a hydrophobic N-terminal region as a signal peptide, which indicates that OTOR is mainly secreted. Researchers found that high expression of OTOR is only seen in the cochlea, demonstrating its importance in hearing. Indeed, loss of the gene produces cochlear dysfunction and otosclerosis, a hearing disorder involving the bony tissue of the ear (HRI). OTOR exerts an influence on the surrounding otic capsule and functions in the extracellular matrix of the membranous portion of the cochlea. Recombinant human Otoraplin (rhOTOR) produced in E. coli is a single non-glycosylated polypeptide chain containing 112 amino acids. rhOTOR has a molecular mass of 12.7 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques.
Reconstitution	Reconstituted in ddH2O at 100 ug/mL.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	12.7 kDa, observed by reducing SDS-PAGE.
Source	E. coli
Host	Human
Accession Number	Q9NRC9
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	Data not available.

Synonyms	FDP, MIAL
Sequence	MVHGIFMDRL ASKKLCADDE CVYTISLASA QEDYNAPDCRFINVKKGQQI YVYSKLVKEN GAGEFWAGSV YGDGQDEMGVVGYFPRNLVK EQRVYQEATK EVPTTDIDFF CE

Purity	95% by SDS-PAGE analysis.
Storage	Lyophilized recombinant human Otoraplin (rhOTOR) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhOTOR remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500371-1	IX03222-1	1mg	$1872		Add to Cart

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