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Home / Proteins & Peptide

omega-Conotoxin MVIIC

SKU : BHP21300023

A Blocker of Presynaptic CaV (N- and P/Q-Type) Channels

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Mfr.No.	C-150, C-150_0.1 mg, C-150_0.25 mg, C-150_0.5 mg, C-150_1 mg, C-150_10 mg, C-150_2.5 mg, C-150_5 mg
Description	A Blocker of Presynaptic CaV (N- and P/Q-Type) Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C106H178N40O32S7
Background	omega-Conotoxin MVIIC blocks CaV2.1 (alpha1A, P/Q-type) and CaV2.2 (alpha1B, N-type) channels.1 The toxin binds with high affinity to CaV2.1 and with lower affinity to CaV2.2 in rabbit brain.2 However, the block by omega-Conotoxin-MVIIC of N-type channels in DRG neurons developed much faster than the block of P-type currents in Purkinje cells.1 The effect of the toxin is modulated by voltage (i.e. it is more potent for inactivated channels).3In addition this toxin was reported to block nicotinic receptors (transiently expressed in Xenopus oocytes) with IC50 of 1.3 uM4 It was also shown to inhibit K+-induced 3H-GABA release in hippocampus in vivo.5 This effect was with high affinity (50% block, 200 nM). The toxin was used to inhibit synaptic transmission in several peripheral preparations.6,7
Biological Activity	omega-Conotoxin MVIIC blocks P/Q- and N-type CaV channels1. omega-Conotoxin MVIIC is also reported to block nicotinic receptors heterologously expressed in Xenopus oocytes with an IC50 of 1.3 uM2.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	2749 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P37300
Concentration	50 nM - 1 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	147794-23-8
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys1-Cys16, Cys8-Cys20 and Cys15-Cys26 Cys26 - C-terminal amidation
Origin	Conus magus (Magical cone)

Synonyms	SNX-230
Gene Id	CACNA1A,CACNA1B
Sequence	CKGKGAPCRKTMYDCCSGSCGRRGKC-NH2
Target	N-type and P/Q-type Ca2+ channels

Country Of Origin	Israel/IL
Purity	>=99% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Liu, H. et al. (1996) J. Biol. Chem. 23, 13804. Stocker, J.W. et al. (1997) J. Neurosci. 17, 3002. Herrero, C.J. et al. (1999) Br. J. Pharmacol. 127, 1375. Newcomb, R. and Palma, A. (1994) Brain. Res. 638, 95. Vega, T. et al. (1995) Eur. J. Pharmacol. 276, 231. Hirata, H. et al. (1997) Eur. J. Pharmacol. 321, 217. McDonough, S.I. et al. (1996) J. Neurosci. 16, 2612. Herrero, C.J. et al. (1999) Br. J. Pharmacol. 127, 1375. McDonough, S.I. et al. (1996) J. Neurosci. 16, 2612

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300023-1	C-150_0.1 mg	0.1 mg	$130		Add to Cart
BHP21300023-2	C-150_0.25 mg	0.25 mg	$218		Add to Cart
BHP21300023-3	C-150_0.5 mg	0.5 mg	$351		Add to Cart
BHP21300023-4	C-150_1 mg	1 mg	$560		Add to Cart
BHP21300023-5	C-150_10 mg	10 mg	$2859		Add to Cart
BHP21300023-6	C-150_2.5 mg	2.5 mg	$1117		Add to Cart
BHP21300023-7	C-150_5 mg	5 mg	$1788		Add to Cart

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