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Home / Proteins & Peptide

omega-Conotoxin GVIA

SKU : BHP21300033

A Blocker of N-Type Ca2+ Channels

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Mfr.No.	C-300, C-300_0.1 mg, C-300_0.25 mg, C-300_0.5 mg, C-300_1 mg, C-300_10 mg, C-300_2.5 mg, C-300_5 mg
Description	A Blocker of N-Type Ca2+ Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C120H182N38O43S6
Background	omega-Conotoxin GVIA is a synthetic toxin originally isolated from the Conus geographus. omega-Conotoxin GVIA is a specific blocker of CaV2.2 Ca2+ channels. It specifically blocks N-type CaV channels by binding to the CaV2.2 alpha1 subunit (alpha1B) and its action is only partially reversible.2,3 In accordance, it inhibits synaptic transmission in many systems.4 It is also reported to antagonize P2X receptors.5 The toxin is used to specifically investigate CaV2.2 channel's contributions (by subtraction of the activity before and during perfusion of the toxin). Alternatively, it is used to eliminate the N-type channel contribution to highlight some other channel or enzyme activity. omega-Conotoxin GVIA was also used to purify the channel protein using immunoprecipitation techniques and to label and localize channels and synapses.6
Biological Activity	omega-Conotoxin GVIA specifically and reversibly blocks N-type CaV channels1 and is reported to antagonize P2X receptors2.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	3037 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P01522
Concentration	20 nM - 1 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Cited Application: Electrophysiology Is Toxin: Yes
Cas Number	106375-28-4
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys1-Cys16, Cys8-Cys19 and Cys15-Cys26 X = Hydroxyproline Tyr27 - C-terminal amidation
Origin	Conus geographus (Geography cone) (Nubecula geographus)

Synonyms	SNX-124
Gene Id	CACNA1B
Sequence	CKSXGSSCSXTSYNCCRSCNXYTKRCY-NH2
Target	N-type Ca2+ channels

Country Of Origin	Israel/IL
Purity	>=99% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Olivera, B.M. et al. (1984) Biochemistry 23, 5087. McCleskey, E.W. et al. (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 4327. Feng, Z.P. et al. (2001) J. Biol. Chem. 276, 15728. Kerr, L.M. and Yoshikami, D. (1984) Nature 308, 282. Lalo, U.V. et al. (2001) Brain Res. Bull. 54, 507. Pravettoni, E. et al. (2000) Dev. Biol. 227, 581. McCleskey, E.W. et al. (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 4327. Lalo, U.V. et al. (2001) Brain Res. Bull. 54, 507.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300033-1	C-300_0.1 mg	0.1 mg	$86		Add to Cart
BHP21300033-2	C-300_0.25 mg	0.25 mg	$185		Add to Cart
BHP21300033-3	C-300_0.5 mg	0.5 mg	$240		Add to Cart
BHP21300033-4	C-300_1 mg	1 mg	$438		Add to Cart
BHP21300033-5	C-300_10 mg	10 mg	$2836		Add to Cart
BHP21300033-6	C-300_2.5 mg	2.5 mg	$985		Add to Cart
BHP21300033-7	C-300_5 mg	5 mg	$1772		Add to Cart

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