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Home / Proteins & Peptide

NT-4, Mouse

SKU : BHP18500341

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Mfr.No.	IX03180, IX03180-1, IX03180-10, IX03180-50
Description	Neurotrophin-4 (NT-4) is a small secreted cytokine, and belongs to the Neurotrophin (NT) family, which also includes Brain Derived Neurotropic Factor (BDNF), Nerve Growth Factor (NGF), and NT-3. NT family members are all derived from similar sized protein precursors, composed of N-terminal propeptides and C-terminal mature domains, which are separated by posttranslational proteolytic cleavage. NT-4 (along with NT-3) is foundin the brains of mammals . In vivo, NT-4 binds to the common receptor, p75NTR, and a tyrosine kinase receptor, TrkB. The heterotrimeric complex activates the NFkappaB transcription factor. NT-4 is essential for the differentiation and wiring regulation of the central and peripheral nervous systems during development, and is related to important diseases including Alzheimer s.Recombinant mouse Neurotrophin-4 (rmNT-4) produced in E. coli is a noncovalently linked homodimer containing two non-glycosylated polypeptide chainsof 131 amino acids. A fully biologically active molecule, rmNT-4 has a molecular mass of 14.0kDaanalyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques.
Reconstitution	Reconstituted in 50mM acetic acid or ddH2O at 100 ug/mL.
Formulation	Lyophilized after extensive dialysis against 50mM acetic acid.
Molecular Weight	14.0 kDa, observed by reducing SDS-PAGE.
Source	E. coli
Host	Mouse
Accession Number	Q80VU4
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	ED50 1ug/mL, measured by a cell proliferation assay usingC6cells, corresponding to a specific activity of1x 103 units/mg.

Synonyms	Neurotrophin-4, Neurotrophic 4/5 (NT-4/NT-5)
Sequence	MGVSETAPAS RRGELAVCDA VSGWVTDRRT AVDLRGREVEVLGEVPAAGG SPLRQYFFET RCKAESAGEG GPGVGGGGCRGVDRRHWLSE CKAKQSYVRA LTADSQGRVG WRWIRIDTACVCTLLSRTGR A

Purity	95% by SDS-PAGEanalysis.
Storage	Lyophilized recombinant mouse Neurotrophin-4 (rmNT-4) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rmNT-4 remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500341-1	IX03180-1	1mg	$2621		Add to Cart
BHP18500341-2	IX03180-10	10ug	$107		Add to Cart
BHP18500341-3	IX03180-50	50ug	$344		Add to Cart

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