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Home / Proteins & Peptide

Noggin, Human(CHO-expressed)

SKU : BHP18500367

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iXCells Biotechnologies

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Mfr.No.	IX03212, IX03212-10, IX03212-50
Description	Noggin, also known as NOG, is a homodimeric glycoprotein that bindsto and modulates the activity of TGF-beta family ligands. It is expressed in condensing cartilage and immature chondrocytes. Noggin antagonizes bone morphogenetic protein (BMP) activities by blocking epitopes on BMPs needed for binding to their receptors. Noggin has been shown to be involved in many developmental processes, such as neural tube formation and joint formation. During development, Noggin diffuses through extracellular matrices and forms morphogenic gradients, regulating cellular responses dependent on the local concentration of the signaling molecule.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	29-31kDa, observed by reducing SDS-PAGE.
Source	CHO
Host	Human
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	ED502.5 ng/ml, measured in a bioassay using ATDC5 cells in the presence of 10ng/ml human BMP-4.

Synonyms	NOG
Sequence	QHYLHIRPAP SDNLPLVDLI EHPDPIFDPK EKDLNETLLRSLLGGHYDPG FMATSPPEDR PGGGGGAAGG AEDLAELDQLLRQRPSGAMP SEIKGLEFSE GLAQGKKQRL SKKLRRKLQMWLWSQTFCPV LYAWNDLGSR FWPRYVKVGS CFSKRSCSVPEGMVCKPSKS VHLTVLRWRC QRRGGQRCGW IPIQYPIISECKCSC

Purity	95% as analyzed by SDS-PAGE.
Storage	Lyophilized recombinant human Noggin remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, human Nogginshould be stable up to 1 week at 4°C or up to 2 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500367-1	IX03212-10	10ug	$82		Add to Cart
BHP18500367-2	IX03212-50	50ug	$245		Add to Cart

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