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Home / Proteins & Peptide

Mouse IL-4 protein

SKU : BHP13700098

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Abbkine Scientific Co., Ltd.

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Mfr.No.	PRP100498
Alternative Names	BSF-1; Il-4; Interleukin-4; IL4
Background	Interleukin-4, also known as IL-4, is a secreted protein which belongs to the IL-4 / IL-13 family. Interleukin-4 / IL-4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation. It enhances both secretion and cell surface expression of IgE and IgG1. Interleukin-4 / IL-4 also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Interleukin-4 is essential for the switching of B cells to IgE antibody production and for the maturation of T helper (Th) cells toward the Th2 phenotype. It participates in at least several B-cell activation processes as well as of other cell types. However, studies show that double mutant (Q116D, Y119D) of the murine IL-4 protein (QY), both glutamine 116 and tyrosine 119, which binds to the IL-4 receptor alpha, completely inhibites in a dose-dependent manner the IL-4-induced proliferation of lipopolysaccharide-stimulated murine splenic B-cells, of the murine T cell line CTLL-2, and of the murine pre-B-cell line BA/F3. QY also inhibited the IL-4-stimulated up-regulation of CD23 expression by lipopolysaccharide-stimulated murine splenic B-cells and abolished tyrosine phosphorylation of the transcription factor Stat6 and the tyrosine kinase Jak3 in IL-4-stimulated BA/F3 cells.
Immunogen Region	PRP100498
Tag	IL-4
Description	Mouse IL-4 protein, expressed in E. coli
Formulation	Lyophilized from sterile PBS, pH 7.4.
Molecular Weight	13.4 kDa
Usage	Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Mouse IL4 protein in sterile ddH2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.
Accession Number	NP_067258.1
Precautions	The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Bioactivity	Measured in a cell proliferation assay using HT-2 mouse T cells. The ED50 for this effect is typically 0.4-2 ng/mL.The ED50 for this effect is typically 0.4-2 ng/mL.
Protein Length	The recombinant mouse IL-4 consists of 119 amino acids and predicts a molecular mass of 13.4 KDa. It migrates as an approximately 14 KDa band in SDS-PAGE under reducing conditions.
Others	Preparation Method: E. coli

Sequence	Amino acid sequence derived from mouse IL-4 (NP_067258.1) (His23-Ser140) was expressed with a N-terminal Met.

Purity	> 90 % as determined by SDS-PAGE
Storage	Lyophilized Mouse IL-4 proteinshould be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.92% HSA or BSA). Please prevent freeze-thaw cycles.

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SKU	Supplier No.	Size	Your price	Quantity
BHP13700098	PRP100498	5 ug	$159		Add to Cart
BHP13700098	PRP100498	100 ug	$1299		Add to Cart
BHP13700098	PRP100498	1 mg	$9569		Add to Cart

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