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Home / Proteins & Peptide

MIP-5/CCL15 (92aa), Human

SKU : BHP18500374

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iXCells Biotechnologies

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Mfr.No.	IX03225, IX03225-1, IX03225-25, IX03225-5
Reconstitution	Reconstituted in ddH2O at 100 ug/mL.
Description	Macrophage Inflammatory Protein-5 (MIP-5/CCL15) is a chemokine originally identified in the human hemofiltrate, thus it is also named Hemofiltrate CC Chemokine-2 (HCC-2). MIP-5 belongs to the CCL chemokine family, and its receptors are G-protein coupled receptors CCR1 and CCR3, with CCR1 being the major one. MIP-5 is mainly expressed in heart and skeletal muscle, and CCR1 is expressed on Th1 and Th2 cells in human cord blood lymphocytes. In vivo, MIP-5 promotes the accumulation of immature myeloid cells and the expansion of metastatic foci in the lever. MIP-5 contributes to severe asthma, sarcoidosis, and atherosclerosis;however, MIP-5 can also inhibit stem cell proliferation, implicating its therapeutic potential as an alternative to high dose chemotherapy.Recombinant human MIP-5/CCL15 (rhMIP-5/CCL15) produced in E.coli is a single non-glycosylated polypeptide chain containing 92 amino acids. A fully biologically active molecule, rhMIP-5/CCL15 has a molecular mass of 10.2 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	10.2 kDa, observed by reducing SDS-PAGE.
Source	E. coli
Host	Human
Accession Number	Q16663
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	ED50 2 ug/mL, measured by the FLIPR assay using CHO cells transfected with human CCR1, the receptor of human CCL15, corresponding to a specific activity of 500 units/mg.

Synonyms	HCC-2, LKN-1, MIP-1 delta
Sequence	QFTNDAETEL MMSKLPLENP VVLNSFHFAA DCCTSYISQSIPCSLMKSYF ETSSECSKPG VIFLTKKGRQ VCAKPSGPGVQDCMKKLKPY SI

Purity	95% by SDS-PAGE analysis.
Storage	Lyophilized recombinant human MIP-5/CCL15 (rhMIP-5/CCL15) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhMIP-5/CCL15 remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500374-1	IX03225-1	1mg	$1872		Add to Cart
BHP18500374-2	IX03225-25	25ug	$120		Add to Cart
BHP18500374-3	IX03225-5	5ug	$49		Add to Cart

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