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Home / Proteins & Peptide

MCP-1/CCL2, Rat

SKU : BHP18500426

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iXCells Biotechnologies

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Mfr.No.	IX03285, IX03285-25, IX03285-5
Description	Chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemotactic protein 1 (MCP1) and small inducible cytokine A2. CCL2 is a small cytokine that belongs to the CC chemokine family. CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection. CCL2 is implicated in the pathogeneses of several diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis and atherosclerosis. CCL2 is anchored in the plasma membrane of endothelial cells by glycosaminoglycan side chains of proteoglycans. CCL2 is primarily secreted by monocytes, macrophages and dendritic cells. CCL2 can signal through the CCR2 receptor.Recombinant rat MCP-1/CCL2 produced in HEK293 cells is a polypeptide chain containing 125 amino acids. A fully biologically active molecule, rrMCP-1/CCL2 has a molecular mass of 10-15 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	10~15 kDa, observed by reducing SDS-PAGE.
Source	HEK 293
Host	Rat
Accession Number	P14844
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	The EC50 value of rat MCP-1/CCL2 on Ca2+ mobilization assay in CHO-K1/G?15/rCCR2 cells (human G?15 and rat CCR2 stably expressed in CHO-K1 cells) is less than 0.3 ug/ml.

Synonyms	MCP-1, MCAF, JE, Monocyte Chemotactic Protein-1 (MCP-1), CCL2
Sequence	QPDAVNAPLT CCYSFTGKMI PMSRLENYKR ITSSRCPKEAVVFVTKLKRE ICADPNKEWV QKYIRKLDQN QVRSETTVFYKIASTLRTSA PLNVNLTHKS EANASTLFST TTSSTSVEVTSMTEN

Purity	98% as analyzed by SDS-PAGE.
Storage	Lyophilized recombinant Rat MCP-1/CCL2 remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Rat MCP-1/CCL2 should be stable up to 1 week at 4°C or up to 3 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500426-1	IX03285-25	25ug	$120		Add to Cart
BHP18500426-2	IX03285-5	5ug	$63		Add to Cart

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