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Home / Proteins & Peptide

Maurocalcine

SKU : BHP21300105

A Ryanodine Receptor 1, 2 & 3 Modulator

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Mfr.No.	RTM-100, RTM-100_0.1 mg, RTM-100_0.25 mg, RTM-100_0.5 mg, RTM-100_1 mg, RTM-100_10 mg, RTM-100_5 mg
Description	A Ryanodine Receptor 1, 2 & 3 Modulator
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C156H270N56O46S6
Background	Maurocalcine (MCa) is a peptidyl toxin originally isolated from the venom of the scorpion Scorpio maurus palmatus.Native MCa is present at a low concentration in the venom (0.5% of total protein). This 33-mer basic peptide contains three disulfide bridges and has 82% sequence homology to Imperatoxin A (IpTxa), a scorpion toxin from the venom of Pandinus imperator. MCa shares the highly basic structural domain identified in peptide A - a segment of the dihydropyridine receptor and IpTxa which is important for interactions with ryanodine receptors. MCa also appears to share the same features as the so-called cell-penetrating peptides which allows the toxin to efficiently penetrate various cell types without expending metabolic energy or using an endocytotic mechanisM1-4In vitro, electrophysiological experiments based on recordings of single channels incorporated into planar lipid bilayers showed that MCa potently and reversibly modifies channel gating behavior of the ryanodine receptor 1 (RyR1) by inducing prominent subconductance behavior.1,2Similar to IpTxa, MCa-modified channels can reversibly shuttle between subconductance states and fast gating states. The actions of these peptides were also found to be additive with those of ryanodine, resulting in additional sub-states along with the ryanodine-locked half-conducting state. However, the predominant subconductance induced by MCa differs from that of IpTxa. At a holding potential of +40 mV, the predominant substates induced by sMCa and IpTxa are 48 and 28% of the full conductance, respectively, suggesting that the structural difference in these peptides may induce slightly different channel conformations that stabilize different unitary conductances.5
Biological Activity	Maurocalcine is an agonist of Ryanodine receptor channel (RyR) types 1' 2 and 3.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	3858.6 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Recombinant, E. coli
Accession Number	P60254
Concentration	200 - 400 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	269745-22-4
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys3-Cys17, Cys10-Cys21 and Cys16-Cys32
Origin	Scorpio maurus palmatus (Israeli golden scorpion)

Synonyms	MCa, Maurocalcin
Gene Id	RYR1,RYR2,RYR3
Sequence	GDCLPHLKLCKENKDCCSKKCKRRGTNIEKRCR-OH
Target	Ryanodine receptors

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Calcium imaging assay

Reference	Fajloun, Z. et al. (2000) FEBS Lett. 469, 179. Mosbah, A. et al. (1998) 6^eme Rencontre en Toxinologie, Société française pour l'étude des toxines, Paris. August 1-4. Estève, E. et al. (2005) J. Biol. Chem. 280, 12833. Chen , L. et al. (2003) J. Biol. Chem. 278, 16095. Tripathy, A. et al. (1998) J. Gen. Physiol. 111, 679.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300105-1	RTM-100_0.1 mg	0.1 mg	$130		Add to Cart
BHP21300105-2	RTM-100_0.25 mg	0.25 mg	$295		Add to Cart
BHP21300105-3	RTM-100_0.5 mg	0.5 mg	$471		Add to Cart
BHP21300105-4	RTM-100_1 mg	1 mg	$753		Add to Cart
BHP21300105-5	RTM-100_10 mg	10 mg	$4818		Add to Cart
BHP21300105-6	RTM-100_5 mg	5 mg	$3012		Add to Cart

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