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Home / Proteins & Peptide

M-CSF, Human

SKU : BHP18500138

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iXCells Biotechnologies

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Mfr.No.	IX02914, IX02914-1, IX02914-10, IX02914-100
Description	Macrophage Colony-Stimulating Factor 1 (M-CSF), involved especially in monocytopoiesis,(1)is a hematopoietic growth factor. In mammals, it exits three isoforms, which invariably share an N-terminal 32-aa signal peptide, a 149-residue growth factor domain, a 21-residue transmembrane region and a 37-aa cytoplasmictail(2). The biological activity of human M-CSF is maintained within the 149-aa growth factor domain(3), and it is only active in the disulfide-linked dimeric?form(4), which is bonded at Cys63.Recombinant human Macrophage Colony-Stimulating Factor 1 (rhM-CSF) produced in E. coli is a disulfide-linked homodimer containing two non-glycosylated?polypeptide chains of 159 amino acids each. A fully biologically active molecule, rhM-CSF has a molecular mass of 28 kDaanalyzed by non-reducing SDS-PAGE and is obtained by proprietary refolding and chromatographic techniques.
Reconstitution	Reconstituted in ddH2O or PBS or Tris-HCl, pH 8.0 at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against 50 mM Tris-HCl, pH 8.0.
Molecular Weight	28 kDa, observed by non-reducing SDS-PAGE.
Source	E. coli
Host	Human
Endotoxin Level	1 EU/ug, determined by LAL method.
Bioactivity	ED50 of 1 - 3 ng/ml, measured by cell proliferation assay of M-NFS-60, corresponding to a specific activity of 3.3 x 105-1 x 106 units/mg.

Synonyms	Macrophage Colony Stimulating Factor, CSF-1, Lanimostim, MCSF, MGC31930, M-CSF.
Sequence	MEEVSEYCSH MIGSGHLQSL QRLIDSQMET SCQITFEFVDQEQLKDPVCY LKKAFLLVQD IMEDTMRFRD NTPNAIAIVQLQELSLRLKS CFTKDYEEHD KACVRTFYET PLQLLEKVKNVFNETKNLLD KDWNIFSKNC NNSFAECSSQ GHERQSEGS

Purity	95% as analyzed by non-reducing SDS-PAGE.
Storage	Lyophilized recombinant human Macrophage Colony-Stimulating Factor 1 (rhM-CSF) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhM-CSF should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500138-1	IX02914-1	1mg	$2621		Add to Cart
BHP18500138-2	IX02914-10	10ug	$107		Add to Cart
BHP18500138-3	IX02914-100	100ug	$563		Add to Cart

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