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Home / Proteins & Peptide

Lys-Bradykinin

SKU : BHP21300060

A Ligand of B2 Bradykinin G-Protein Coupled Receptor

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Mfr.No.	GPK-100, GPK-100_0.5 mg, GPK-100_1 mg, GPK-100_25 mg, GPK-100_5 mg
Description	A Ligand of B2 Bradykinin G-Protein Coupled Receptor
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C56H85N17O12
Background	Kinins are small peptides rapidly produced following tissue injury that serve as important modulators of inflammation and pain. In the periphery, the actions of kinins include vasodilatation, increased vascular permeability, stimulation of immune cells, and induction of pain. Kinins in the central nervous system (CNS) appear to initiate a similar cascade of events leading to neural tissue damage as well as long lasting disturbances affecting blood-brain barrier function1.Kinins such as Bradykinin (BK), Lys-BK, desArg9-BK, and Lys-desArg9-BK exert their action via two distinct G protein-coupled receptors (GPCR): the B1 Bradykinin receptor (BKRB1) and the B2 Bradykinin receptor (BKRB2)2.Activation of BKRB2 liberates mediators of vascular tone, fibrinolysis, and pain. BKRB2, which mediates most of the physiological effects of kinins, as well as BKRB1, represent potential therapeutic targets for treatment of inflammatory disorders and cardiovascular diseases.Expression of BKRB1 is inducible upon various types of tissue injury and by inflammatory mediators such as bacterial lipopolysaccharide (LPS) and cytokines. A low level of expression of BKRB1 in the CNS of rodent and primates was recently demonstrated3. BKRB2 is constitutively and widely expressed throughout the CNS and peripheral nervous system and on various cell types including endothelial cells, nerve fibers, leukocytes, and mast cells3-5.Lys-Bradykinin is an endogenous nonspecific agonist for BKRB1and BKRB2, with some specificity towards the BKRB26. Activation of Bradykinin receptors with Lys-Bradykinin may induce intracellular Ca2+ elevation7. 100 nM Lys-Bradykinin induced Ca2+ transients in rat aortic endothelium cells (RAEC) (see figure here and review in reference #8).
Biological Activity	Lys-Bradykinin is an endogenous nonspecific agonist for the B1 and B2 Bradykinin receptors, with some specificity towards the B2 receptor1. Activation of Bradykinin receptors with Lys-Bradykinin may induce intracellular Ca2+ increase1.
Formulation	Lyophilized Powder.
Molecular Weight	1188.38 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Concentration	100 nM - 1 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: No
Cas Number	0342-10-9
UNSPSC Code	12352202
Lead Time	1-2 Business Days

Synonyms	Kallidin, lysyl-bradykinin
Gene Id	BDKRB2
Sequence	KRPPGFSPFR-OH
Target	B2 bradykinin receptor

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Calcium imaging assay

Reference	Bockmann, S. and Paegelow, I. (2000) J. Leukoc. Biol. 68, 587. Hess, J.F. et al. (2004) J. Pharmacol. Exp. Ther. 310, 488. Souza, D.G. et al. (2004) J. Immunol. 172, 2542. Calixto, J.B. et al. (2000) Pain 87, 1. Leeb-Lundberg, L. M. F. et al. (2005) Pharmacol. Rev. 57, 27. Pallone, T. L. et al. (1998) Am. J. Physiol. 274, H752. Karaki, H. et al. (1998) Pharmacol. Rev. 49, 157. Walker, K. et al (1995) Neurochem. Int. 26, 1. Pallone, T. L. et al. (1998) Am. J. Physiol. 274, H752. Leeb-Lundberg, L. M. F. et al. (2005) Pharmacol. Rev. 57, 27.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300060-1	GPK-100_0.5 mg	0.5 mg	$55		Add to Cart
BHP21300060-2	GPK-100_1 mg	1 mg	$75		Add to Cart
BHP21300060-3	GPK-100_25 mg	25 mg	$223		Add to Cart
BHP21300060-4	GPK-100_5 mg	5 mg	$91		Add to Cart

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