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Home / Proteins & Peptide

LR<sup>3</sup>-IGF-I (Receptor Grade), Human

SKU : BHP18500338

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iXCells Biotechnologies

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Mfr.No.	IX03177, IX03177-1, IX03177-100
Description	IGF-1 is a well-characterized basic peptide secreted by the liver that circulates in the blood. It has growth-regulating, insulin-like, mitogenic activities. IGF-1 is a growth factor that has a major, but not absolute, dependence on somatotropin. It is believed to be mainly active in adults in contrast to IGF-2, which is also a major fetal growth factor. Human Long R3 Insulin-like Growth Factor-1 (rhLR3IGF-1) contains an 83 amino acid analog of human IGF-I. Compared to the complete human IGF-I sequence, an addition of the rhLR3IGF-1 includes the substitution of an Arg for the Glu at position 3 (hence R3)and a13 amino acid extension peptide at the N-terminus. An enhanced potency is due to the markedly decreased binding of human Long-R3-IGF-I to IGF binding proteins which normally inhibit the biological actions of IGFs. RhLR3IGF-1 is properly folded under oxidizing conditions and then purified by proprietary chromatographic techniques.
Reconstitution	Reconstituted in 10mM HCl at 1mg/ml. Use a 0.22 um membrane for filter?Sterilization.
Formulation	Lyophilized after dissolved in 48%acetonitrile and 0.1% TFA
Molecular Weight	9.1±0.9 KDa, observed by reducing SDS-PAGE.
Source	E. coli
Host	Human
Endotoxin Level	?1 EU/ug, determined by LAL method.
Bioactivity	ED50 ?10 ng/ml, measured by the dose-dependantproliferation of CHO cells, corresponding to a specific activity of 1.0x 105 units/mg.

Synonyms	Human LR3 Insulin-like Growth Factor-I (LR3-IGF-I) (Receptor Grade)
Sequence	MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNKPTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPAKSA

Purity	95% by SDS-PAGE.
Storage	Lyophilized recombinant human Long R³ Insulin-like Growth Factor-1 (rhLR³ IGF-1) remains stable up to 6 months at lower than -70°C from date of receipt. Stock solution of peptide can be stored at least 3 months at -20°C. Avoid repeated freeze-thaw cycles.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500338-1	IX03177-1	1mg	$174		Add to Cart
BHP18500338-2	IX03177-100	100ug	$49		Add to Cart

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