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Home / Proteins & Peptide

LD78-beta/CCL3L1, Human

SKU : BHP18500375

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iXCells Biotechnologies

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Mfr.No.	IX03226, IX03226-1, IX03226-25, IX03226-5
Description	LD78-beta/CCL3L1 is a proinflammatory chemokine and the isoform of Macrophage Inflammatory Protein-1 alpha (MIP-1 alpha). LD78-beta is secreted by most mature leukocytes, predominantly macrophages, and its major receptor is the G-protein coupled receptor CCR5, which is also the co-receptor used by the HIV-1 virus for cell entry. LD78-beta has superior antiviral activity and induces a variety of immune cells, particularly CD8+ T cells and immature dendritic cells. LD78-beta attracts lymphocytes and macrophages to sites of inflammation and infection, and its functions are inhibited by Interleukin-4, Interleukin-10, and Interleukin-13. Importantly, the copy number variation of LD78-beta is associated with HIV susceptibility, indicating LD78-beta s critical role in the disease.Recombinant human LD78-beta/CCL3L1 (rhLD78-beta) produced in E.coli is a single non-glycosylated polypeptide chain containing 70 amino acids. A fully biologically active molecule, rhLD78-beta has a molecular mass of 7.8 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Reconstitution	Reconstituted in ddH2O at 100 ug/mL.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	7.8 kDa, observed by reducing SDS-PAGE.
Source	E. coli
Host	Human
Accession Number	P16619
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	ED500.4 ug/mL, measured by the FLIPR assay using CHO cells transfected with human CCR5, the receptor of human CCL3L1, corresponding to a specific activity of 2.5x103 units/mg.

Synonyms	SCYA3L1
Sequence	APLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPSVIFLTKRGRQV CADPSEEWVQ KYVSDLELSA

Purity	95% by SDS-PAGE and HPLC analysis.
Storage	Lyophilized recombinant human LD78-beta/CCL3L1 (rhLD78-beta) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhLD78-beta remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500375-1	IX03226-1	1mg	$1872		Add to Cart
BHP18500375-2	IX03226-25	25ug	$120		Add to Cart
BHP18500375-3	IX03226-5	5ug	$50		Add to Cart

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