Human lethal(3) malignant brain tumor-like protein 3 (L3MBTL3), GenBank Accession No. NM_032438, a.a. 229-547 with N-terminal GST-tag, MW = 63.6 kDa, expressed in an E. coli cell expression system.
host species: E. coli
Host species: E. coli
Background
PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis.
Immunogen Region
229-547
Tag
N-terminal GST-tag
Formulation
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 1.8 mM glutathione, 0.007% Tween-20, and 20% glycerol.
Species
Human
Application
Useful for the study of Polycomb group (PcG) proteins, protein binding assays, screening inhibitors, and selectivity profiling.
Notes
Avoid freeze/thaw cycles.
GenBank
NM_032438
Mw(kda)
63.6 kDa
Synonyms
lethal(3) malignant brain tumor-like protein 3
Uniprot
Q96JM7
Shipping Temperature
-80°C (dry ice)
Format
Aqueous buffer solution
Storage
At least 6 months at -80°C.
Reference
1. James, L.I., et al., Nat Chem Biol. 2013 Mar;9(3):184-91. 2. Arai, S., Miyazaki, T., EMBO J. 2005 May 18;24(10):1863-73.