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Home / Proteins & Peptide

KRAS (G12C), Isoform A, His-Tag, GDP-Loaded

SKU : BHP18200989

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BPS Bioscience

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Mfr.No.	100640
Description	Human KRAS, also known as C-K-RAS, CFC2, and K-RAS2A, GenBank Accession No. NM_033360, a.a. 2-186 with G12C mutation and N-terminal His-tag, expressed in an E. coli expression system. MW=23 kDa. KRAS (G12C) His-Tag (Biohippo #100413), is loaded with GDP. Unbound GDP was removed by spin column. Ready for use in the GDP/GTP exchange assay or as a negative control for KRAS-RAF interaction.
Immunogen Region	2-186
Tag	N-terminal His-tag
Formulation	20 mM HEPES, pH 7.4, 150 mM NaCl, and 1 mM DTT.
Species	Human
Application	Useful for nucleotide exchange assay, KRAS(G12C) inhibitors screening, and selectivity profiling.
Notes	GDP loaded KRAS(G12C) was tested for binding to the RBD of Raf1. GDP-loaded KRAS(G12C) was compared with GppNHp-loaded KRAS(G12C) (Biohippo #100641) for RBD-RAF1 (Biohippo #100519) binding by Bio-layer Interferometry (GATOR, Probe Life) and AlphaScreening (PerkinElmer). Avoid freeze/thaw cycles.
GenBank	NM_033360
Mw(kda)	23 kDa

Synonyms	C-K-RAS, CFC2, K-RAS2A
Uniprot	P01116

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -70°C.

Reference	1. Ostrem, J. M., et al., Nature. 2013;503:548-551. 2. Patricelli, M. P., et al., Cancer Discovery. 2016;6:316-329.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200989	100640	4 x 60 ug	$1182.50		Add to Cart

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