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Home / Proteins & Peptide

IP-10/CXCL10, Human

SKU : BHP18500179

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iXCells Biotechnologies

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Mfr.No.	IX02971, IX02971-1, IX02971-10, IX02971-50
Description	IP-10/CXCL10 also known as CXCL10, is originally identified as an IFN-gamma-inducible gene in monocytes, fibroblasts and endothelial cells. It has since been shown that IP-10 mRNA is also induced by LPS, IL-1beta, TNF-alpha, IL-12 and viruses. Additional cell types that have been shown to express IP-10 include activated T-lymphocytes, splenocytes, keratinocytes, osteoblasts, astrocytes, and smooth muscle cells. IP-10 is also expressed in psoriatic and lepromatous lesions of skin. The mouse homologue of human IP-10, Crg-2, has been cloned and shown to share approximately 67% amino acid sequence identity with human IP-10.Recombinant human IP-10/CXCL10 (rhIP-10) produced in E. coli is a single non-glycosylated polypeptide chain containing 78 amino acids. A fully biologically active molecule, rhIP-10 has a molecular mass of 8.6kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques.
Reconstitution	Reconstituted in ddH2O at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against 50mM Tris, pH8.0.
Molecular Weight	8.6 kDa, observed by reducing SDS-PAGE.
Source	E. coli
Host	Human
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	ED50 0.2ug/ml, measured by a cell proliferation assay of HUVEC cells in the presence of 2.5ng/ml h-VEGF, corresponding to a specific activity of 5.0x 103 IU/mg.

Synonyms	Small inducible cytokine B10, CXCL10, 10 kDa interferon-gamma-induced protein, Gamma-IP10, IP-10, chemokine (C-X-C motif) ligand 10, C7, IFI10, INP10, crg-2, mob-1, SCYB10, gIP-10
Sequence	MVPLSRTVRC TCISISNQPV NPRSLEKLEI IPASQFCPRVEIIATMKKKG EKRCLNPESK AIKNLLKAVS KEMSKRSP

Purity	95% by SDS-PAGE and HPLC analyses.
Storage	Lyophilized recombinant human IP-10/CXCL10 (rhIP-10) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhIP-10 should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500179-1	IX02971-1	1mg	$1223		Add to Cart
BHP18500179-2	IX02971-10	10ug	$62		Add to Cart
BHP18500179-3	IX02971-50	50ug	$170		Add to Cart

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