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Home / Proteins & Peptide

IL-1RA, Human

SKU : BHP18500031

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iXCells Biotechnologies

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Mfr.No.	IX02700, IX02700-1, IX02700-100
Description	Interleukin-1 receptor antagonist (IL-1ra) is a member of the IL-1 family. Endogenous IL-1ra is produced in numerous animal disease models as well as in human autoimmune and chronic inflammatory diseases. It binds to IL-1 receptors in competition with IL-1, but does not elicit intracellular response from this binding. Its role in counteracting the proinflammatory effects of IL-1 is being studied by numerous research groups. IL-4 and IL-13 have been shown to amplify the stimulatory effect of IL1-beta on the production of soluble and intracellular forms of IL1-ra.The regulated expression of IL1ra in various cell types has been shown to be influenced by cytokines. In synovial fibroblasts the synthesis of IL-1ra is markedly enhanced by IL-1 , TNF-alpha , or PDGF.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <= -20 °C. Further dilutions should be made in appropriate buffered solutions.
Formulation	Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.
Molecular Weight	Approximately 17.1 kDa, a single non-glycosylated polypeptide chain containing 152 amino acids.
Physical Appearance	Sterile Filtered White lyophilized (freeze-dried) powder.
Source	E. coli
Host	Human
Usage	This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Endotoxin Level	Less than 1 EU/ug of rHuIL-1RA as determined by LAL method.
Bioactivity	Fully biologically active when compared to standard. The ED50 as determined by inhibiting IL-1alpha-dependent proliferation of murine D10S cells is less than 40 ng/ml, corresponding to a specific activity of 2.5 x 104 IU/mg in the presence of 50 pg/ml rHuIL-1alpha.

Synonyms	Interleukin-1 receptor antagonist (IL-1ra), Human;
Sequence	RPSGRKSSKM QAFRIWDVNQ KTFYLRNNQL VAGYLQGPNVNLEEKIDVVP IEPHALFLGI?HGGKMCLSCV KSGDETRLQL EAVNITDLSENRKQDKRFAF IRSDSGPTTS FESAACPGWF?LCTAMEADQP VSLTNMPDEGVMVTKFYFQE DE

Purity	96 % by SDS-PAGE and HPLC analyses.
Storage	This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500031-1	IX02700-1	1mg	$949		Add to Cart
BHP18500031-2	IX02700-100	100ug	$199		Add to Cart

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