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Home / Proteins & Peptide

IL-10, Human(CHO-expressed)

SKU : BHP18500288

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iXCells Biotechnologies

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Mfr.No.	IX03121, IX03121-1, IX03121-10, IX03121-50
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Description	Interleukin-10 (IL-10), initially known as Cytokine Synthesis Inhibitory Factor (CSIF), belongs to the IL-10 family and shares more than 80% sequence homology with Epstein-Barr Virus protein BCRFI. It is produced by many immune cells, such as T-cells, macrophages, mast cells, and dendritic cells. It is usually secreted as a homodimer and, upon binding to its receptor, inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and Th2 cells. It also displays ability to suppress Antigen-Presenting Cell (APC) function. The net effect of Interleukin-10 appears to be inhibitory; however, stimulatory effects, such as stimulation of B cell maturation and antibody production, are also reported.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	18-19 kDa, observed by reducing SDS-PAGE.
Source	CHO
Host	Human
Accession Number	P22301
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	ED50 0.2 ng/ml, measured in a cell proliferation assay using MC/9 cells.

Synonyms	B-TCGF, CSIF, TGIF
Sequence	SPGQGTQSEN SCTHFPGNLP NMLRDLRDAF SRVKTFFQMKDQLDNLLLKE SLLEDFKGYL GCQALSEMIQ FYLEEVMPQAENQDPDIKAH VNSLGENLKT LRLRLRRCHR FLPCENKSKAVEQVKNAFNK LQEKGIYKAM SEFDIFINYI EAYMTMKIRN

Purity	95% as analyzed by SDS-PAGE and HPLC.
Storage	Lyophilized recombinant Human Interleukin-10 remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human Interleukin-10 should be stable up to 1 week at 4°C or up to 2 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500288-1	IX03121-1	1mg	$2621		Add to Cart
BHP18500288-2	IX03121-10	10ug	$107		Add to Cart
BHP18500288-3	IX03121-50	50ug	$344		Add to Cart

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