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Home / Proteins & Peptide

IFN-gamma, Human

SKU : BHP18500139

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iXCells Biotechnologies

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Mfr.No.	IX02915, IX02915-1, IX02915-10, IX02915-100, IX02915-50
Description	Human Interferon gamma (hIFN-gamma) is amacrophage?activating factor and the lone member of Interferon type II.The active form of IFN-gamma is an antiparallel dimer that interacts with the receptor IFN-gammaR1 and sets off IFN-gamma/JAK/STAT pathway. IFN-gamma signaling does diverse biological functions primarily related to host defense and immune regulation, including antiviral and antibacterial defense, apoptosis, inflammation, and innate and acquired immunity. While IFN-gammainduced inflammatory cascade summons a variety of immune?related cell types, such as macrophages, natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), IFN-gamma is also implicated in resistance to NK cell and CTL responses and in immune escape in a variety of cancers. Recombinant human Interferon gamma (rhIFN-gamma) produced in E. coli is a non?glycosylated polypeptide chain of 144 amino acids. A fully biologically active molecule, rhIFN-gamma has a molecular mass of 17 kDa analyzed by reducing SDS?PAGE and is obtained by proprietary refolding and chromatographic techniques.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	17kDa, observed by reducing SDS?PAGE.
Source	E. coli
Host	Human
Endotoxin Level	1 EU/ug, determined by LAL
Bioactivity	ED500.05ng/ml, measured by?cytotoxicity assay using HT?29 cells.

Synonyms	Immune Interferon, type II interferon, T cell interferon, MAF, IFNG, IFG, IFI,IFN-gamma.
Sequence	MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEESDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNVKFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAELSPAAKTGKR KRSQMLFRGR RASQ

Purity	95% as analyzed by reducing SDS?PAGE.
Storage	Lyophilized recombinant human Interferon gamma (rhIFN?gamma) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhIFN-gamma should be stable up to 1 week at 4°C or up to 2 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500139-1	IX02915-1	1mg	$531		Add to Cart
BHP18500139-2	IX02915-10	10ug	$32		Add to Cart
BHP18500139-3	IX02915-100	100ug	$107		Add to Cart
BHP18500139-4	IX02915-50	50ug	$75		Add to Cart

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