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Home / Proteins & Peptide

Iberiotoxin

SKU : BHP21300235

A Potent and Specific Blocker of KCa1.1 K+ Channels

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Mfr.No.	STI-400, STI-400_0.1 mg, STI-400_0.5 mg, STI-400_1 mg, STI-400_10 mg, STI-400_5 mg
Description	A Potent and Specific Blocker of KCa1.1 K+ Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C179H274N50O55S7
Background	Iberiotoxin is a 37 amino acid peptidyl toxin isolated from the scorpion Mesobuthus tamulus and was shown to block large conductance Ca2+-activated K+ channels in smooth muscle cells1. Later it was shown to specifically block KCa1.1 (Slo) channels with Ki of about 1 nM2. In addition, experiments with cloned KCa1.1 channels demonstrate the strong effect of the slobeta subunits on the potency of block by Iberiotoxin3.
Biological Activity	Iberiotoxin is a potent selective blocker of the high conductance Ca2+-activated K+ channels (maxi-K).
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	4230.8 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P24663
Concentration	50 - 100 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Cited Application: Electrophysiology Is Toxin: Yes
Cas Number	129203-60-7
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35 Z = Pyrrolidone carboxylic acid
Origin	Hottentotta tamulus (Eastern Indian scorpion) (Mesobuthus tamulus)

Synonyms	K+ channel toxin alpha-KTx 1.3, IbTx
Gene Id	KCNMA1
Sequence	ZFTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ-OH
Target	KCa1.1 K+ channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Galvez, A. et al. (1990) J. Biol. Chem. 265, 11083. Koschak, A. et al. (1997) Biochemistry 36, 1943. Meera, P. et al. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 5562.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300235-1	STI-400_0.1 mg	0.1 mg	$86		Add to Cart
BHP21300235-2	STI-400_0.5 mg	0.5 mg	$384		Add to Cart
BHP21300235-3	STI-400_1 mg	1 mg	$612		Add to Cart
BHP21300235-4	STI-400_10 mg	10 mg	$3916		Add to Cart
BHP21300235-5	STI-400_5 mg	5 mg	$2448		Add to Cart

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