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Home / Proteins & Peptide

Human Synthetic Amyloid Beta Peptide 1-42 (HFIP treated)

SKU : BHP11901216

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StressMarq Biosciences Inc.

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Mfr.No.	SPR-485, SPR-485B, SPR-485E, SPR-485H
Description	Human Synthetic Amyloid Beta Peptide 1-42 (HFIP treated)
Alternative Names	Abeta Protein, Abeta peptide, Amyloid beta peptide, Beta amyloid peptide, amyloid beta precursor protein peptide, APP
Cellular Localization	Intracellular Vesicles, Cell Membrane
Certificate Of Analysis	Certified >98% pure using mass spec and HPLC.
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Scientific Background	Our amyloid beta peptide 1-42 (Abeta42) is produced synthetically and treated with 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) prior to drying which breaks down pre-formed fibrils and monomerizes the peptide, as previously published (1,2). Upon resuspension in DMSO/dH2O, our Abeta42 presents as a monomeric peptide without fibrils when observed under TEM, AFM and on a Weste Blot with an anti-amyloid beta antibody. In contrast to AB42 oligomer and fibril constructs, our Abeta42 monomers were not toxic to primary rat cortical neurons. In the brain, amyloid beta peptide (Abeta) is generated by protease cleavage of amyloid precursor protein (APP), which aggregates into oligomers, protofibrils, fibrils and ultimately plaques in neurodegenerative diseases. The accumulation of Abeta plaques in the brain is considered a hallmark of Alzheimer s disease (AD), and most of the drugs tested for AD in the past 20 years have targeted amyloid beta accumulation (3). Soluble Abeta oligomers isolated from the brains of AD patients or those generated in vitro potently impaired synapse structure and function (4). Abeta oligomers generated in vitro were toxic to PC12 cells (2) and SH-SY5Y cells (5). Abeta was demonstrated to interact with tauopathies to affect neurodegeneration in AD patients (6) and accumulations of Abeta were shown to be associated with lower survival rates in Parkinson s disease patients with dementia (7).
Species	Human
Specificity	4.5 kDa
Host	Human
Concentration	N/A - dried peptide film
Purification	N/A
Expression System	N/A
Amino Acid Sequence	DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Cite This Product	Human Synthetic Amyloid Beta Peptide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPR-485)
Mol Weight	4.5 kDa
Mw(kda)	4.5 kDa
Nature	Synthetic
Protein Length	42 amino acids

Gross Weight (kg)	1.4
Launch Date	2022/03/03
Net Weight (g)	0.01
Swissprot	P05067
Target Details	Amyloid Beta
Gene Id	351, 351
Research Area	Amyloid, Neurodegeneration, Alzheimer's Disease, Neuroscience
Target	Amyloid Beta, Amyloid Beta

Adr Code	Non-hazardous
Country Of Origin	Canada
Stock Product	Y
Tarriff Code	3822.19.0030
Un Code For Transport	Non-hazardous
Unspsc Code	12352202
Shipping Temperature	Blue Ice or 4°C
Purity	>95%, >98%
Storage Buffer	Dry powder. See "Other Resources" for re-suspension instructions/protocol.
Storage Temperature	-80°C

Applications	In vivo assay, In vitro assay, WB

Reference	1. Stine et al. 2003. JBC. 278(13):11612-22. doi: 10.1074/jbc.M210207200 2. Chromy et al. 2003. Biochemistry. 42:12749-12760. doi: 10.1021/bi030029q 3. Panza et al. 2019. Nat Rev Neurol. 15:73-88 https://doi.org/10.1038/s41582-018-0116-6 4. Shankar et al. 2008. Nat Med. 14(8):837-842. doi: 10.1038/nm1782 5. Kayed et al. 2003. Science. 300(5618): 486-489. doi: 10.1126/science.1079469 6. Want et al. 2016. JAMA Neurol. 73(9):1070-7. doi: 10.1001/jamaneurol.2016.2078 7. Kotzbauer et al. 2012. Arch Neurol. 69(10): 1326-1331. doi: 10.1001/archneurol.2012.1608

Product Manual	Datasheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP11901216-1	SPR-485B	100 ug	$132		Add to Cart
BHP11901216-2	SPR-485E	500 ug	$270		Add to Cart
BHP11901216-3	SPR-485H	1 mg	$435		Add to Cart

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