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Home / Proteins & Peptide

Human SPAM1 Protein, hFc Tag

SKU : BHP18100270

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DIMA Biotechnology

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Mfr.No.	PME101008
Description	Recombinant human SPAM1 protein with C-terminal human Fc tag
Background	Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in eXtracellular matrices and basement membranes. SiX members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was preVIously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal eXpression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene. (proVIded by RefSeq, Mar 2010)
Tag	C-Human Fc tag
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Molecular Weight	The protein has a predicted molecular mass of 77.2 kDa after removal of the signal peptide. The apparent molecular mass of SPAM1-hFc is approXimately 100-130 kDa due to glycosylation.
Host	HEK293
Notes	Research use only

Synonyms	HEL-S-96n; HYA1; HYAL1; HYAL3; HYAL5; PH-20; PH20; SPAG15
Uniprot	P38567
Target	SPAM1

Purity	The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
Storage	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

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SKU	Supplier No.	Size	Your price	Quantity
BHP18100270	PME101008	100 ug	$660		Add to Cart
BHP18100270	PME101008	50 ug	$450		Add to Cart
BHP18100270	PME101008	10 ug	$120		Add to Cart

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