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Home / Proteins & Peptide

Human PRNP / Major prion protein Recombinant Protein

SKU : BHP13800264

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	R9345h
Alternative Names	ASCR,PrP27-30,PrP33-35C,CD230,ALTPRP,PRIP,PRP
Source	E.coli
Species	Homo Sapiens (Human)
Accession Number	AAH22532.1/ncbi
Endotoxin Level	<0.10 EU per 1 μg of the protein by the LAL method
Concentration	Reconstitution Dependent
Form	Liquid
Protein Name	Major prion protein
Entry Function	Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as a agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.
Mw(kda)	9.68

Subunit	Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization (PubMed:11524679, PubMed:11900542, PubMed:14623188, PubMed:17468747, PubMed:19204296, PubMed:19927125, PubMed:20375014, PubMed:20564047). Interacts with GRB2, APP, ERI3/PRNPIP and SYN1. Mislocalized cytosolically exposed PrP interacts with MGRN1; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement (By similarity). Interacts with KIAA1191 (PubMed:21153684). Interacts with ADGRG6.
Gene Name	PRNP
Sequence	23-110aa

Purity	Greater than 95% by SDS-PAGE
Storage	Store at -20°C. (Avoid repeated freezing and thawing.)
Storage Buffer	50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)

Applications	Par, ELISA, AP, WB

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SKU	Supplier No.	Size	Your price	Quantity
BHP13800264	R9345h	50µg	$637.78		Add to Cart
BHP13800264	R9345h	100µg	$904.44		Add to Cart
BHP13800264	R9345h	200µg	$1348.89		Add to Cart
BHP13800264	R9345h	0.5mg	$1971.11		Add to Cart
BHP13800264	R9345h	1mg	$2682.22		Add to Cart
BHP13800264	R9345h	5mg	$4637.78		Add to Cart
BHP13800264	R9345h	10mg	$6148.89		Add to Cart

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