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Home / Proteins & Peptide

Human OTULIN / Ubiquitin thioesterase otulin Recombinant Protein

SKU : BHP13800235

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	R15311h
Alternative Names	Deubiquitinating enzyme otulin,OTU domain-containing deubiquitinase with linear linkage specificity,Ubiquitin thioesterase Gumby,FAM105B
Source	E.coli
Species	Homo Sapiens (Human)
Accession Number	Q96BN8
Endotoxin Level	<0.10 EU per 1 μg of the protein by the LAL method
Concentration	Reconstitution Dependent
Form	Liquid
Protein Name	Ubiquitin thioesterase otulin
Entry Function	Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:27523608, PubMed:27559085, PubMed:24726323, PubMed:24726327). Associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates (PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:24726323, PubMed:24726327). Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PubMed:23708998). Acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex (PubMed:23746843, PubMed:23806334). Required for homeostasis of the LUBAC complex by restricting autoubiquination of the LUBAC complex subunit RNF31 (PubMed:24726323). Some results have suggested that OTULIN function is restricted to homeostasis of the LUBAC complex, because it is not stably associated with TNF or NOD2 receptor signaling complexes (RSCs) (PubMed:26670046). However, further report have shown that it plays active roles in receptor signaling (PubMed:26997266, PubMed:27523608). Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PubMed:27523608). In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation (PubMed:27523608). Plays a key role in innate immune response by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling (PubMed:23806334).
Mw(kda)	27.5

Subunit	Interacts (via the PUB domain) with RNF31 (via the PIM motif); the interaction is direct (PubMed:27523608, PubMed:23708998, PubMed:23746843, PubMed:24726323, PubMed:24726327). Interacts with DVL2.
Gene Name	OTULIN
Sequence	1-250aa

Purity	Greater than 95% by SDS-PAGE
Storage	Store at -20°C. (Avoid repeated freezing and thawing.)
Storage Buffer	50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)

Applications	Par, ELISA, AP, WB

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SKU	Supplier No.	Size	Your price	Quantity
BHP13800235	R15311h	50µg	$637.78		Add to Cart
BHP13800235	R15311h	100µg	$904.44		Add to Cart
BHP13800235	R15311h	200µg	$1348.89		Add to Cart
BHP13800235	R15311h	0.5mg	$1971.11		Add to Cart
BHP13800235	R15311h	1mg	$2682.22		Add to Cart
BHP13800235	R15311h	5mg	$4637.78		Add to Cart
BHP13800235	R15311h	10mg	$6148.89		Add to Cart

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