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Home / Proteins & Peptide

Human MKI67 / Proliferation marker protein Ki-67 Recombinant Protein

SKU : BHP13800343

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	R2047h
Alternative Names	Antigen identified by monoclonal antibody Ki-67,Antigen KI-67
Source	E.coli
Species	Homo Sapiens (Human)
Accession Number	P46013
Endotoxin Level	<0.10 EU per 1 μg of the protein by the LAL method
Concentration	Reconstitution Dependent
Form	Liquid
Protein Name	Proliferation marker protein Ki-67
Entry Function	Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed.
Mw(kda)	23.65

Subunit	Interacts with KIF15 (PubMed:10878014). Interacts (via the FHA domain) with NIFK (PubMed:11342549, PubMed:14659764, PubMed:16244663). Interacts with PPP1CC (PubMed:24867636). Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity (PubMed:19131338, PubMed:23178126).
Gene Name	MKI67
Sequence	101-315aa

Purity	Greater than 95% by SDS-PAGE
Storage	Store at -20°C. (Avoid repeated freezing and thawing.)
Storage Buffer	50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)

Applications	Par, ELISA, AP, WB

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SKU	Supplier No.	Size	Your price	Quantity
BHP13800343	R2047h	50µg	$637.78		Add to Cart
BHP13800343	R2047h	100µg	$904.44		Add to Cart
BHP13800343	R2047h	200µg	$1348.89		Add to Cart
BHP13800343	R2047h	0.5mg	$1971.11		Add to Cart
BHP13800343	R2047h	1mg	$2682.22		Add to Cart
BHP13800343	R2047h	5mg	$4637.78		Add to Cart
BHP13800343	R2047h	10mg	$6148.89		Add to Cart

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