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Home / Proteins & Peptide

Human LRP8 / Low-density lipoprotein receptor-related protein 8 Recombinant Protein

SKU : BHP13800171

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	R10006h
Alternative Names	Apolipoprotein E receptor 2,APOER2
Source	E.coli
Species	Homo Sapiens (Human)
Accession Number	Q14114
Endotoxin Level	<0.10 EU per 1 μg of the protein by the LAL method
Concentration	Reconstitution Dependent
Form	Liquid
Protein Name	Low-density lipoprotein receptor-related protein 8
Entry Function	Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor.
Mw(kda)	11.22

Subunit	Reelin associates with two or more receptor molecules. Interacts with DAB1 and JNK-interacting proteins. Interacts with SNX17 (By similarity). Interacts with PCSK9.
Gene Name	LRP8
Sequence	52-153aa

Purity	Greater than 95% by SDS-PAGE
Storage	Store at -20°C. (Avoid repeated freezing and thawing.)
Storage Buffer	50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)

Applications	Par, ELISA, AP, WB

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SKU	Supplier No.	Size	Your price	Quantity
BHP13800171	R10006h	50µg	$637.78		Add to Cart
BHP13800171	R10006h	100µg	$904.44		Add to Cart
BHP13800171	R10006h	200µg	$1348.89		Add to Cart
BHP13800171	R10006h	0.5mg	$1971.11		Add to Cart
BHP13800171	R10006h	1mg	$2682.22		Add to Cart
BHP13800171	R10006h	5mg	$4637.78		Add to Cart
BHP13800171	R10006h	10mg	$6148.89		Add to Cart

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