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Home / Proteins & Peptide

Human LCN2 / Neutrophil gelatinase-associated lipocalin Recombinant Protein

SKU : BHP13800213

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	R1388h
Alternative Names	25 kDa alpha-2-microglobulin-related subunit of MMP-9,Lipocalin-2,Oncogene 24p3,Siderocalin LCN2,p25,HNL,NGAL
Source	E.coli
Species	Homo Sapiens (Human)
Accession Number	P80188
Endotoxin Level	<0.10 EU per 1 μg of the protein by the LAL method
Concentration	Reconstitution Dependent
Form	Liquid
Protein Name	Neutrophil gelatinase-associated lipocalin
Entry Function	Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
Mw(kda)	19.58

Subunit	Homodimer; disulfide-linked. Heterodimer; disulfide-linked with MMP9.
Gene Name	LCN2
Sequence	21-198aa

Purity	Greater than 95% by SDS-PAGE
Storage	Store at -20°C. (Avoid repeated freezing and thawing.)
Storage Buffer	50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)

Applications	Par, ELISA, AP, WB

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SKU	Supplier No.	Size	Your price	Quantity
BHP13800213	R1388h	50µg	$637.78		Add to Cart
BHP13800213	R1388h	100µg	$904.44		Add to Cart
BHP13800213	R1388h	200µg	$1348.89		Add to Cart
BHP13800213	R1388h	0.5mg	$1971.11		Add to Cart
BHP13800213	R1388h	1mg	$2682.22		Add to Cart
BHP13800213	R1388h	5mg	$4637.78		Add to Cart
BHP13800213	R1388h	10mg	$6148.89		Add to Cart

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