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Home / Proteins & Peptide

Human IL-18 protein

SKU : BHP13700042

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Abbkine Scientific Co., Ltd.

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Mfr.No.	PRP100039
Description	Human IL-18 protein, expressed in E. coli
Alternative Names	IGIF; IL-18; IL-1g; IL1F4; Interleukin 18; Interleukin-18; IL18
Background	Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of IL-18 and IL-12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL-18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. IL-18 is an IL-1?like cytokine that requires cleavage with caspase-1 to become active, was found to increase IgE production in a CD4+ T cells-, IL-4? and STAT6?dependent fashion. IL-18 and T cell receptor?mediated stimulation could induce naïve CD4+ T cells to develop into IL-4?producing cells in vitro. Thus, caspase-1 and IL-18 may be critical in regulation of IgE production in vivo, providing a potential therapeutic target for allergic disorders. IL-18 production in primary synovial cultures and purified synovial fibroblasts was, in turn, upregulated by TNF-alpha and IL-1beta, suggesting that monokine expression can feed back to promote Th1 cell development in synovial membrane. Besides, synergistic combinations of IL-18, IL-12, and IL-15 may be of importance in sustaining both Th1 responses and monokine production in RA.
Immunogen Region	PRP100039
Tag	IL-18
Formulation	Lyophilized from sterile PBS, pH 7.4.
Molecular Weight	18.2 kDa
Usage	Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human IL18 protein in sterile ddH2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.
Accession Number	NP_001553.1
Precautions	The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Protein Length	The recombinant human IL-18 consists 157 amino acids and predicts a molecular mass of 18.2 kDa.
Others	Preparation Method: E. coli

Sequence	Amino acid sequence derived from human IL-18 (NP_001553.1) (Tyr37-Asp193) was expressed.

Purity	> 85 % as determined by SDS-PAGE.
Storage	Lyophilized Human IL-18 proteinshould be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.32% HSA or BSA). Please prevent freeze-thaw cycles.

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SKU	Supplier No.	Size	Your price	Quantity
BHP13700042	PRP100039	10 ug	$189		Add to Cart
BHP13700042	PRP100039	100 ug	$1029		Add to Cart
BHP13700042	PRP100039	1 mg	$6219		Add to Cart

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