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Home / Proteins & Peptide

Histone Octamer (full length), His-tag

SKU : BHP18200456

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BPS Bioscience

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Mfr.No.	52037
Description	Human recombinant histone octamer consisting of 2 molecules each of histones H2A (a.a. 2-130(end)), H2B (a.a. 2-126(end)), H3 (a.a. 2-137(end)), and H4 (a.a. 2-103(end)), expressed in an E. coli expression system. GenBank Accession Nos. are NM_033445, NM_003528, NM_003532, and NM_003548, respectively. Each histone protein has an N-terminal His-tag. Global MW = 113.8 kDa. Host cell line: E. coli
Background	The histone octamer is composed of a central heterotetramer of two copies of both histones H3 and H4, flanked by two heterodimers of histones H2A and H2B. The octamer assembles when the H3/H4 tetramer complexes with two H2A/H2B dimers. These histones of the histone octamer all contain N-terminal tails that emanate from their central histone folds and are targets for epigenetic modification.
Tag	N-terminal His-tag
Formulation	10 mM Tris pH 7.4, 2 M NaCl, 1 mM EDTA, 5 mM BME, and 10% glycerol
Species	Human
Application	Substrate for histone methyltransferase or acetyltransferase assays. Ideal for screening small molecular inhibitors of histone methyltransferases and acetyltransferases for drug discovery and HTS applications. Since the recombinant histone proteins in thi
Notes	Avoid freeze/thaw cycles.
GenBank	NM_033445, NM_003528, NM_003532, NM_003548
Mw(kda)	116 kDa

Uniprot	Q7L7L0, Q16778, P68431, P62805

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	Stable at -80°C for at least 6 months from date of receipt, when stored as directed

Reference	1. Miller KM, Jackson SP. Biochem Soc Trans 40(2):370-6 (2012). 2. Raut VV, Pandey SM, Sainis JK. Ann Bot 108(7):1235-46 (2011). 3. Park K, Fasman GD. Biochemistry. 1987 Dec 15;26(25):8042-5. 4. Meagher, R.B., Mussar, K.J., Epigenetics Chromatin 2012 Jul 20,5(1):11.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200456	52037	100 ug	$528		Add to Cart

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