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Home / Proteins & Peptide

HDAC3/NcoR2 Complex, His-tag

SKU : BHP18200303

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BPS Bioscience

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Mfr.No.	50003
Description	Complex of human HDAC3 , GenBank Accession No. NM_003883, full length with C-terminal His-tag, MW= 49.7 kDa, and human NCOR2 , a.a. 395- 489, GenBank Accession No. NM_006312, N-terminal GST-tag, MW= 37.6 kDa, co-expressed in baculovirus expression system. Host cell line: Sf9 cells Specific activity: >=3000 pmol/min/ug.
Immunogen Region	full length HDAC3, 395- 489 NCOR2
Tag	C-terminal His-tag
Formulation	40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 20% glycerol, 200 mM imidazole
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	25 mM Tris/HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl₂, and 0.1 mg/ml BSA, 20 uM BPS HDAC substrate 3 (Catalog #50037), and HDAC3/NcoR2. Incubation condition: 30 min at 37°C, followed by HDAC developer (Catalog #50030) for 15 min at room temperature. Fluorescence intensity is measured at ex360/em460. Avoid freeze/thaw cycles.
GenBank	NM_003883
Mw(kda)	87.3 kDa (complex)

Synonyms	histone deacetylase 3, HDAC-3
Uniprot	O15379

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Gregoire, S. et al. Mol. Cell. Biol. 27 (4), 1280-1295 (2007) 2. Escaffit, F. et al., Mol. Cell. Biol. 27 (2), 554-567 (2007)Application References: 1. Wang, Y., et al. Chem Biol. 2015 Feb 19;22(2):273-84. doi: 10.1016/j.chembiol.2014.12.015. Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases (2015) 2.Mechanism of Action of 2-Aminobenzamide HDAC Inhibitors in Reversing Gene Silencing in Friedreich's Ataxia (2015) 3.Design, synthesis, 3D pharmacophore, QSAR, and docking studies of carboxylic acid derivatives as Histone Deacetylase inhibitors and cytotoxic agents (2014) 4.Discovery of a small molecule agonist of phosphatidylinositol 3-kinase p110alpha that reactivates latent HIV-1 (2014) 5.A chimeric SERM-histone deacetylase inhibitor approach to breast cancer therapy (2014) 6.Wang, C., et al. J Med Chem. 2014 Oct 9;57(19):7999-8009. doi: 10.1021/jm500872p. In Vivo Imaging of Histone Deacetylases (HDACs) in the Central Nervous System and Major Peripheral Organs (2014) 7.Selective HDAC Inhibition for the Disruption of Latent HIV-1 Infection (2014) 8.Class I HDAC imaging using ( (3)H)CI-994 autoradiography (2013) 9. Fass, D.M., et al. Neuropharmacology. 2013 Jan; 64: 8196. Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity (2013) 10.FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors (2013) 11. Baud, MGJ, et al. ChemMedChem. 2013 Jan;8(1):149-56. doi: 10.1002/cmdc.201200450. Highly ligand efficient and selective N-2-(Thioethyl)picolinamide histone deacetylase inhibitors inspired by the natural product psammaplin A (2013) 12.Imaging epigenetic regulation by histone deacetylases in the brain using PET/MRI with ¹¸F-FAHA (2013) 13. Marek, M., et al. PLoS Pathog. 2013;9(9):e1003645. doi: 10.1371/journal.ppat.1003645. Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni (2013)

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200303	50003	50 ug	$533.50		Add to Cart

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