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Home / Proteins & Peptide

HDAC2, FLAG-tag

SKU : BHP18200322

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BPS Bioscience

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Mfr.No.	50052
Description	Human HDAC2 , GenBank Accession No. Q92769, full length with C-terminal FLAG-tag, MW= 60 kDa, expressed in baculovirus expression system. Host cell line: Sf9 cells Specific activity: >=1020 pmol/min/ug.
Immunogen Region	full length
Tag	C-terminal FLAG-tag
Formulation	45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 90 ug/ml FLAG peptide and 10% glycerol.
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	25 mM of Tris-HCl , pH 8.0, 137 mM of NaCl, 2.7 mM of KCl, 1 mM of MgCl₂, 0.1 mg/ml BSA, 20 uM BPS HDAC substrate 3, BPS catalog #: 50037, 30 min at 37°C, followed by HDAC developer (Catalog #50030) for 15 min at room temperature. Fluorescence intensity is measured at ex360/em460. Avoid freeze/thaw cycles.
GenBank	NM_001527
Mw(kda)	60 kDa

Synonyms	histone deacetylase 2, HDAC-2
Uniprot	Q92769

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Yang,W.M. et al., Proc. Natl. Acad. Sci. U.S.A. 93 (23), 12845-12850 (1996). 2. Mungall, A.J. et al., Nature 425 (6960), 805-811 (2003).Application Reference(s): 1.Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers (2015) 2.A chimeric SERM-histone deacetylase inhibitor approach to breast cancer therapy (2014) 3. Wang, C., et al. J Med Chem. 2014 Oct 9;57(19):7999-8009. doi: 10.1021/jm500872p. In Vivo Imaging of Histone Deacetylases (HDACs) in the Central Nervous System and Major Peripheral Organs (2014) 4.A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests (2013) 5.Class I HDAC imaging using ( (3)H)CI-994 autoradiography (2013) 6. Fass, D.M., et al. Neuropharmacology. 2013 Jan; 64: 8196. Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity (2013) 7.FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors (2013) 8. Baud, MGJ, et al. ChemMedChem. 2013 Jan;8(1):149-56. doi: 10.1002/cmdc.201200450. Highly ligand efficient and selective N-2-(Thioethyl)picolinamide histone deacetylase inhibitors inspired by the natural product psammaplin A (2013) 9.Imaging epigenetic regulation by histone deacetylases in the brain using PET/MRI with ¹¸F-FAHA (2013) Pavlik, C.M., et al. J Nat Prod. 2013 Nov 22;76(11):2026-33. doi: 10.1021/np400198r. Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp (2013) 11.Total synthesis and full histone deacetylase inhibitory profiling of Azumamides A-E as well as beta²- epi-Azumamide E and beta³-epi-Azumamide E (2013)

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200322	50052	50 ug	$484		Add to Cart

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