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Home / Proteins & Peptide

GRO alpha/CXCL1, Human

SKU : BHP18500442

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Mfr.No.	IX03303, IX03303-1, IX03303-25, IX03303-5
Description	Chemokine (C-X-C motif) ligand 1 (CXCL1) is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO-alpha, KC, neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-alpha). Human GRO-alpha, GRO-beta (MIP2alpha),and GRO-gamma (MIP2beta)are products of three distinct, nonallelichuman genes. GRO-beta and GRO-gamma share 90% and 86% amino acid sequence homology with GROalpha, respectively. All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors.GRO expression is inducible by serum or PDGF and/or by a variety of inflammatory mediators, such as IL-1 and TNF, in monocytes, fibroblasts, melanocytes and epithelial cells. In certain tumor cell lines, GRO is expressed constitutively.Similar to other alpha chemokines, the three GRO proteins are potent neutrophil attractants and activators. Additionally, these chemokines are also active toward basophils.All three GROs can bind with high affinity to the IL-8 receptor type B.Recombinant Human GRO alpha/CXCL1 produced in E.coli is a single non-glycosylated polypeptide chain containing 73 amino acids. A fully biologically active molecule, rhGRO alpha/CXCL1 has a molecular mass of 7.8 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	7.8 kDa, observed by reducing SDS-PAGE.
Source	E. coli
Accession Number	P09341
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	The EC50 value of human GRO alpha/CXCL1 on Ca2+ mobilization assay in CHO-K1/Galpha15/hCXCR2 cells (human Galpha15 and human CXCR2 stably expressed in CHO-K1 cells) is less than 100ng/ml.

Synonyms	Growth Regulated Protein/Melanoma Growth Stimulatory Activity, GRO ?, MGSA ?, CXCL1, NAP-3, GRO1, KC (murine), CINC (rat)
Sequence	Ala35-Asn107 (Accession #:P09341)

Purity	95% as analyzed by SDS-PAGE.
Storage	Lyophilized recombinant Human GRO alpha /CXCL1 remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human GRO alpha /CXCL1 should be stable up to 1 week at 4°C or up to 3 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500442-1	IX03303-1	1mg	$1373		Add to Cart
BHP18500442-2	IX03303-25	25ug	$199		Add to Cart
BHP18500442-3	IX03303-5	5ug	$74		Add to Cart

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