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Home / Proteins & Peptide

Galanin (2-11)

SKU : BHP21300057

A Selective and Potent Agonist of Galanin 2/3 Receptors

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Alomone Labs

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Mfr.No.	GPG-150, GPG-150_0.5 mg, GPG-150_1 mg, GPG-150_2.5 mg, GPG-150_5 mg
Description	A Selective and Potent Agonist of Galanin 2/3 Receptors
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. Soluble in DMSO. Prepare a concentrated stock solution by dissolving the lyophilized peptide in DMSO first (e.g., at a concentration between 100-1000x of the final working concentration). Once the peptide is completely dissolved in DMSO, slowly dilute the solution into the working buffer (or water) to the desired final working concentration. Centrifuge all product preparations before use. Avoid multiple freeze-thaw cycles to maintain biological activity. It is recommended to keep the DMSO concentration as low as possible. For cell assays, a final concentration of 0.1%0.5% DMSO (v/v) is considered safe. For other experiments, a 5% DMSO (v/v) concentration is recommended.
Molecular Formula	C54H81N13O14
Background	Galanin (2-11) is a neuropeptide that acts as a selective potent galanin 2 and 3 receptor (GalR2/3) agonist. Galanin is a C-terminally amidated 29-residue peptide deriving its name from the N-terminal glycine and C-terminal alanine residue. In humans the peptide contains additional nonamidated serine residue at C terminus. Galanin was firstly isolated from porcine intestine and shown to be widely distributed through the central and peripheral nervous system1-3.Its biological activity includes contraction or relaxation of gut smooth muscles, inhibition of insulin and somatostatin release, and modulation of hormone secretion from the pituitary and adrenal gland. It is believed that galanin plays an important role as a neuromodulator of endocrine secretion and synaptic transmission1.Galanin receptors belong to the family of G-protein coupled receptors and consist of three subtypes: GalR1, GalR2, and GalR3. Additional studies show that galanin and its receptors are involved in the transmission and modulation of nociception2.
Biological Activity	A Galanin 2/3 receptor agonist1.
Formulation	Lyophilized in 50% acteonotrile.
Molecular Weight	1136 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes). The lyophilizate may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. Soluble in DMSO. Prepare a concentrated stock solution by dissolving the lyophilized peptide in DMSO first (e.g., at a concentration between 100-1000x of the final working concentration). Once the peptide is completely dissolved in DMSO, slowly dilute the solution into the working buffer (or water) to the desired final working concentration. Centrifuge all product preparations before use. It is recommended to keep the DMSO concentration as low as possible. For cell assays, a final concentration of 0.1%0.5% DMSO (v/v) is considered safe. For other experiments, a 5% DMSO (v/v) concentration is recommended.
Source	Synthetic peptide
Concentration	0.1 - 10 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: No
Cas Number	367518-31-8
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Leu10 - C-terminal amidation

Synonyms	AR-M1896, Gal (2-11) amide
Gene Id	GALR2, GALR3
Sequence	WTLNSAGYLL-NH2
Target	Galanin 2/3 receptors

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: Store the reconstituted solution for the shortest time possible at -20°C. We do not recommend storing the product in working solution for longer than one day. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Store the reconstituted solution at -20°C for the shortest time possible. Avoid multiple freeze-thaw cycles. We do not recommend storing the product in working solutions for longer than a day.

Applications	Aequorin functional assay, Calcium imaging assay

Reference	Liu, M. et al. (2013) PLoS One 8, e63473. Schmidt W.E. et al. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 11435. Zhang, M.L. et al. (2017) Sci. Rep. 7, 45930. Lu, X. et al. (2005) Neuropeptides 39, 143.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300057-1	GPG-150_0.5 mg	0.5 mg	$117		Add to Cart
BHP21300057-2	GPG-150_1 mg	1 mg	$162		Add to Cart
BHP21300057-3	GPG-150_2.5 mg	2.5 mg	$282		Add to Cart
BHP21300057-4	GPG-150_5 mg	5 mg	$406		Add to Cart

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